Words similar to kynureninase
Example sentences for: kynureninase
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The kynureninase of rat and human liver has an order-of-magnitude preference for 3-hydroxykynurenine [ 37], in contrast to a microbial kynureninase that exhibits a very high preference for kynurenine [ 38].
kynU encoding kynureninase and kprS (alternative name: prsA ) encoding PRPP synthase are located at the 3' end of the C. psittaci trp operon (see Figure 1).
It is perhaps intriguing that when C. psittaci kynureninase (KynU) was used as a query sequence, the top hits returned from BLAST were the KynU orthologs from man and mouse.
The host enzyme catalyzing the latter reaction is, in fact, a kynureninase which is a homolog of the C. psittaci KynU.
Starvation for host-derived L-tryptophan, which is initiated by induction of indoleamine dioxygenase by IFN-γ, undoubtedly triggers derepression of the entire tryptophan operon, including the genes encoding PRPP synthase and kynureninase.