Words similar to kynureninase
Example sentences for: kynureninase
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The kynureninase of rat and human liver has an order-of-magnitude preference for 3-hydroxykynurenine [ 37], in contrast to a microbial kynureninase that exhibits a very high preference for kynurenine [ 38].
It is perhaps intriguing that when C. psittaci kynureninase (KynU) was used as a query sequence, the top hits returned from BLAST were the KynU orthologs from man and mouse.
The host enzyme catalyzing the latter reaction is, in fact, a kynureninase which is a homolog of the C. psittaci KynU.
kynU encoding kynureninase and kprS (alternative name: prsA ) encoding PRPP synthase are located at the 3' end of the C. psittaci trp operon (see Figure 1).
Starvation for host-derived L-tryptophan, which is initiated by induction of indoleamine dioxygenase by IFN-γ, undoubtedly triggers derepression of the entire tryptophan operon, including the genes encoding PRPP synthase and kynureninase.