Words similar to kxd

Example sentences for: kxd

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Previous studies have shown that Rab24 exhibits several unusual characteristics that distinguish it from other members of the Rab GTPase family [ 25 ] . The studies described in this report demonstrate that putative dominant-negative mutant forms of Rab24, bearing single amino acid substitutions in the conserved N(T)KxD nucleotide binding motif ( e.g. , D123I and T120A), are targeted to numerous inclusion bodies that disrupt the nuclear envelope and enter the nuclear compartment.
Therefore, it appears that although the C-terminal domain of Rab24 is required to promote its incorporation into inclusion bodies, it does so only when expressed in the context of a Rab GTPase with a mutation in the N(T)KxD nucleotide binding motif.
Several laboratories have shown that in addition to mutations in the N(T)KxD motif, which reduce overall nucleotide binding, dominant-negative Rab constructs can be generated by introducing amino acid substitutions ( e.g. , asparagine) at the position cognate to Ras S17 ( i.e. , S22 in Rab24) [ 31 40 41 42 ] . Such proteins are thought to be locked in an inactive GDP-bound state because the mutation markedly reduces their affinity for GTP, compared to GDP [ 42 ] . As shown in Fig.
We also verified that the unique behavior of the Rab24 mutant was not related specifically to the substitution at the aspartate position in the N(T)KxD motif.
Similar mutations in the N(T)KxD motif of other Rab proteins typically yield soluble cytoplasmic proteins.