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Example sentences for: kxd

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8D), but instead exhibited a diffuse distribution similar to Rab1B(N121I) and other Rabs with mutations in the N(T)KxD motif (see Fig.
An extensive body of published work supports the notion that Rab proteins bearing mutations in the N(T)KxD nucleotide binding motif function as dominant-suppressors of their endogenous cellular counterparts.
Therefore, pending further investigation, we cannot rule out the alternative hypothesis that mutations in the N(T)KxD motif of Rab24, combined with features in the C-terminal domain, cause Rab24 to misfold in a unique manner, attracting non-physiological protein partners that can promote aggregation and nuclear localization.
Therefore, it appears that although the C-terminal domain of Rab24 is required to promote its incorporation into inclusion bodies, it does so only when expressed in the context of a Rab GTPase with a mutation in the N(T)KxD nucleotide binding motif.
Several laboratories have shown that in addition to mutations in the N(T)KxD motif, which reduce overall nucleotide binding, dominant-negative Rab constructs can be generated by introducing amino acid substitutions ( e.g. , asparagine) at the position cognate to Ras S17 ( i.e. , S22 in Rab24) [ 31 40 41 42 ] . Such proteins are thought to be locked in an inactive GDP-bound state because the mutation markedly reduces their affinity for GTP, compared to GDP [ 42 ] . As shown in Fig.