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Example sentences for: kusaka

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We have shown previously that antagonism of the slowly activating non-inactivating granulosa K +current (I Ks ) enhances basal progesterone production by depolarizing membrane potential and thus enhancing calcium influx via pimozide-sensitive Ca 2+channels [ 18 ] . In contrast, Kusaka [ 21 ] showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and LH-stimulated progesterone production.
4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.