Words similar to kk
Example sentences for: kk
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The KK, TK, and KKTK mutant versions of Boi1-PH contain substitutions at positions in the PH domain that were predicted to be involved in binding PIP 2 . PIP 2 /PS vesicles did not stimulate the proteolysis of any of these mutant versions of Boi1-PH, suggesting that each mutant is indeed impaired in the ability to associate with PIP 2 and/or PS.
However, these analyses suggest that the KK substitutions may impair binding in a different manner than do the TK substitutions.
5B, top and second panels, lanes 3-6), suggesting that the KK substitutions impair binding to PIP 2 . In contrast, the TK mutant version of Boi1-PH appeared to retain a slight ability to pellet with PIP 2 /PS vesicles (Fig.
In the presence of vesicles composed of only PS, an appreciable amount of Boi1-PH(KK) pelleted (Fig.
5A, bottom panel, lanes 5 and 6), consistent with the view that the KKTK mutant is more severely impaired in the ability to bind PIP 2 than are the KK and TK mutants.