Words similar to kinking
Example sentences for: kinking
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Similar results were reported for this FLAG epitope-tagged mutant in other cell lines [ 26 ] . Second, the tail kinking and "waltzing" phenotypes in our transgenic animals expressing stabilized human β-catenin are highly similar to those seen in Fused mice [ 29 ] . Fused encodes the murine Axin homologue, and mutation of this gene results in activation of Wnt signaling [ 30 ] . The tail kinking in our animals presumably results from low level expression of the mutant transgene in utero during vertebral patterning.
Several of these animals had glomerulonephritis, but overall the causes of death were variable, and, except for tail kinking, no clear pattern of extra-CNS defects emerged in the transgenic animals.
The most striking phenotype was the "kinking" of tails seen in lines Mut-1 and Mut-3 (Table 1).
The tail kinking in these mice is highly similar to the phenotype seen in Axin mutants with activated Wnt signaling, indicating the β-catenin protein expressed in our transgenic mice is functional.