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Example sentences for: kila-n
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The RHA, φ31ORF238-N and MSV199 domains, while less versatile in their connections, tend to combine with the same domains, and in the same orientation, as Bro-N and KilA-N (Figure 2b), which suggests an analogous function, such as DNA binding.
PSI-BLAST searches seeded with the KilA-N domains from a diverse set of viral and bacterial proteins also consistently recovered fungal transcription factors that are involved in cell-cycle-specific gene expression and filamentation, with E-values of borderline statistical significance (0.
As an example, a profile seeded with the MBP1p APSES domain and including all APSES domains in the NR database detects the N. meningitidis protein NMA1544 (gi:11290039) with an E-value of 0.1 in iteration 3. Given the availability of the three-dimensional structure of the APSES domain of the MBP1p protein [ 16, 17], we investigated this potential relationship using the KilA-N domain sequences for sequence-structure threading of the PDB database with the 3DPSSM, PSIPRED and combined-fold prediction algorithms.
The phyletic patterns of the KilA-N and APSES domains have interesting implications for the origin of the fungal transcription factors.
Accordingly, this domain was named the KilA-N (terminal) domain (Table 2).