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Example sentences for: kila-n
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The sequence relationship with the APSES domain, taken together with the evidence of DNA binding by the D6R/N1R protein [ 12], suggests that the KilA-N domain is a previously undetected DNA-binding domain that is prevalent in the viral world.
These observations suggest that the APSES, LAGLIDADG and TEN domains, together with the KilA-N domain, define a novel nucleic-acid-binding fold with a conserved (β 2 α) 2 core (Figure 1b).
Just as the APSES domain appears to be a derivative of a KilA-N domain captured by the cellular genome, the TEN domains appear to have been derived through the ancient cellular capture of an inactive LAGLIDADG-like domain [ 32].
An alternative scenario, that the viral KilA-N domains were acquired from the fungal APSES domain, is also imaginable.
The KilA-N and the Bro-N domains show additional parallels in the domain architectures of the corresponding proteins.
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