Words similar to kila-n
Example sentences for: kila-n
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The majority of the domains with which the KilA-N and Bro-N domains combine in multidomain proteins are restricted to proteins encoded by temperate bacteriophages and large eukaryotic DNA viruses (the exceptions are a few domains that are common in cellular proteomes, such as HTH, CCCH and RING finger).
KilA-N and Bro-N domains combine with overlapping sets of carboxy-terminal domains, which, in turn, combine with several additional domains, resulting in an extensive network of 18 domains that are predominantly specific to large DNA viruses and six domains acquired by these viruses from the host genomes (18 + 6 = 24).
In order to identify the entire repertoire of domains involved in these domain-shuffling events, we systematically explored all domains that combined with the KilA-N and Bro-N domains and compiled a list of domains with which the latter combined in other multidomain proteins (Table 2, Figure 2a).
The entire network consists of 24 domains, of which Bro-N and KilA-N domains show by far the greatest number of connections (12 and 7, respectively) compared to other domains.
Threading with the combined-fold prediction algorithm also gave the MBP1p APSES domain as the best hit with a very high Z-score (Z = 60), suggesting that the KilA-N domain was highly likely to adopt the same fold as the APSES domain.
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