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Example sentences for: kila-n
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Both of them show expansions in particular viral genomes, for example KilA-N in FPV and Bro-N in certain baculoviruses, and the entomopoxvirus MSV.
Just as the APSES domain appears to be a derivative of a KilA-N domain captured by the cellular genome, the TEN domains appear to have been derived through the ancient cellular capture of an inactive LAGLIDADG-like domain [ 32].
Structural comparisons using the DALI program [ 20], indicated that the core fold shared by the KilA-N and APSES domains is more distantly related to the LAGLIDADG site-specific DNA endonucleases and the amino-terminal domain of the tRNA splicing endonucleases (TEN domain) (Figure 1b) [ 21].
The majority of the domains with which the KilA-N and Bro-N domains combine in multidomain proteins are restricted to proteins encoded by temperate bacteriophages and large eukaryotic DNA viruses (the exceptions are a few domains that are common in cellular proteomes, such as HTH, CCCH and RING finger).
In all proteins shown to contain the KilA-N domain, it occurs at the extreme amino terminus accompanied by a wide range of distinct carboxy-terminal domains other than the RING finger or CCCH domains that are seen in the poxviruses (Figure 2and see below).