Example sentences for: keratinocytes

How can you use “keratinocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Similar structures also occur in primary keratinocytes mediating intercellular adhesion [ 31].

  • Although SPARC is required for migration of dermal fibroblasts into the wound site, it is apparently not essential to the motility of keratinocytes since reepithelialization appears normal in SPARC-null mice.

  • The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.

  • Other groups of functionally related genes are shown in Figure 7: some are ion channels (Figure 7d, whereas others are associated with keratinocytes (Figure 7c) or involved in the respiratory chain (Figure 7e).

  • TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .


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