Words similar to kelch

Example sentences for: kelch

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The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.
The BTBD proteins contain an amino terminal BTB/POZ domain as well as a C-terminal region that is related to proteins that contain the kelch domain.
The BTBD proteins belong to the last category, although they are distantly related to kelch proteins (~25% identical over ~250 aa), they lack the residues that are characteristic of kelch repeats, a double glycine sequence and a tyrosine separated from a tryptophan by precisely 6 residues [ 35 37 ] .