Words similar to jnk

Example sentences for: jnk

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The MAP kinase pathway consists of 3 major parallel pathways designated as the ERK (p42/44, Extracellular signal-Regulated Kinase), SAPK/JNK (p46, Stress-Activated Protein Kinase/ c-Jun NH2-terminal Kinase) and p38 pathways [ 12 13 14 ] . Activation of each pathway above involves phosphorylation of a number of upstream and downstream family members of the pathway.
During growth factor deprivation induced PCD in neuronal PC12 cells, there is a sustained activation of the JNK and p38 pathways while the activities of ERK pathway is inhibited.
For JNK assays, cells were resuspended in RPMI 1640 supplemented with 2.5% fetal calf serum, and following stimulation whole cell lysates were analysed by Western blotting with anti-active JNK antiserum.
For example, the stress kinase JNK1 was activated during TLK286 induced apoptosis [ 17 ] and JNK is known to be activated during apoptosis induced by a variety of stress stimuli [ 18 ] . However, in HL60/TLK286 resistant cells, we observed an overexpression of two phosphatases PP2 (AA599092) and MKP5 (AA056608) involved in JNK dephosphorylation and inactivation (Table 2).
5-HT, acting via the 5-HT 2A receptor, is a known activator of the ERK pathway in vascular smooth muscle cells [ 2 22 ] . In these studies we tested the hypothesis that 5-HT would activate the JNK and p38 pathways in rat aortic vascular smooth muscle cells.