Words similar to jnk

Example sentences for: jnk

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Biochemical studies of Btk-deficient B cells have shown Btk to be necessary for BCR-induced phospholipase C-γ2 (PLCγ2) phosphorylation, calcium mobilization, extracellular signal-regulated kinase (ERK) and c-Jun NH 2 -terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation, NF-κB activation and apoptosis [ 7, 8, 9, 10, 11, 12].
In Fig 3B, JNK activity was measured by Western blotting whole cell lysates with phosphospecific JNK antiserum.
Known activators include reactive oxygen species [ 3 4 ] , growth factors [ 5 ] , and agonists of G-protein coupled receptors [ 6 7 ] . The two other MAPK pathways, the JNK and p38 pathways, have been implicated in a variety of similar cellular functions.
It was reported that rabbits fed with high-cholesterol diet exhibited high JNK protein levels and JNK activity in their atherosclerotic lesions, and oxidized LDL caused JNK activation in cultured smooth muscle cells [ 18 ] . Based on this study, there is a possibility that cholesterol oxides in oxidized LDL were responsible for those previous observations.
In DT40 B cells, apoptosis induction by Btk:ER may be a consequence of its capacity to activate JNK, since in these cells JNK activation correlates more closely with apoptosis than does ERK activation.