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Bacteria: Aae, Aquifex aeolicus; Bap, Buchnera aphidicola; Bbu, Borrelia burgdorferi; Bsu, Bacillus subtilis; Bhal, Bacillus halodurans; Cje, Campylobacter jejuni; Cpn, Chlamydophila pneumoniae; Ctr, Chlamydia trachomatis; Dra, Deinococcus radiodurans; Eco, Escherichia coli; Hin, Haemophilus influenzae; Hpy, Helicobacter pylori; Mge, Mycoplasma genitalium; Mpn, Mycoplasma pneumoniae; Mtu, Mycobacterium tuberculosis; Nme, Neisseria meningitidis; Pae, Pseudomonas aeruginosa; Rpr, Rickettsia prowazekii; Syn, Synechocystis sp.; Tma, Thermotoga maritima; Tpa, Treponema pallidum; Vch, Vibrio cholerae; Xfa, Xylella fastidiosa . Eukaryote: Sce, Saccharomyces cerevisiae . Archaea: Ape, Aeropyrum pernix; Afu, Archaeoglobus fulgidus; Hbs, Halobacterium sp.; Mja, Methanococcus jannaschii; Mth, Methanobacterium thermoautotrophicum; Pho, Pyrococcus horikoshii; Pab, Pyrococcus abyssi; Tac, Thermoplasma acidophilum .
A few tracer studies in the older literature have indicated derivation of α-ketobutyrate from pyruvate rather than from threonine [ 32, 33], and (R)-citramalate synthase activity has been shown recently in M. jannaschii (MJ1392) [ 34].
Data from the following species were assembled into presumptive orthology groups (hereafter, proteins) and aligned [ 36 ] : Aquifex aeolicus , Bacillus subtilis , Borrelia burgdorferi , Chlamydia trachomatis , Escherichia coli , Haemophilus influenzae , Helicobacter pylori, Mycobacterium tuberculosis, Mycoplasma genitalium, Mycoplasma pneumoniae , Rickettsia prowazekii, Synechocystis sp., and Treponema pallidum (Eubacteria), Archaeoglobus fulgidus, Methanobacterium thermoautotrophicum, Methanococcus jannaschii, Pyrococcus abyssi , and P. horikoshii (Archaebacteria: Euryarchaeota), and Arabidopsis thaliana, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Gallus gallus, Homo sapiens, Mus musculus, Oryza saticva, Plasmodium falciparum, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Trypanosoma sp. , and Xenopus laevis (Eukaryota).
Neisseria meningitidis (Neime), Pasteurella multocida (Pasmu), Psudomonas aeruginosa (Pseae), Rickettsia prowazekii (Ricpr), Staphyloccocus aureus (Staau), Streptococcus pyogenes (Strpy), Synechocystis PCC6803 (SynPC), Thermotoga maritima (Thema), Treponema pallidum (Trepa), Ureaplasma urealyticum (Ureur), Vibrio cholerae (Vibch), Xylella fastidiosa (Xylfa), and ten archaea: Aeropyrum pernix (Aerpe), Archaeoglobus fulgidus (Arcfu), Halobacterium sp. (Halsp), Methanobacterium thermoautotrophicum (Metth), Methanococcus jannaschii (Metja), Pyrococcus horikoshii (Pyrho), Pyrococcus abyssi (Pyrab), Sulfolobus solfataricus (Sulso), Thermoplasma acidophilum (Theac), Thermoplasma volcanium (Thevo).
It has been shown that M. jannaschii ProRS, a class II synthetase that is unrelated to the class I CysRS, substituted for the missing CysRS activity [ 15, 16, 17].