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Example sentences for: izumi

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An alanine substitution mutant, N226A, of a conserved residue at the end of molego 7a that forms a hydrogen bond with the second phosphate group downstream of the abasic site, had enhanced APE activity but increased Km and Kd values, similar to an alanine mutant of R177, which binds to the same site, reported previously [ 34 ] . A combination of the two mutants, N226A and R177A, substantially reduced the ability of APE1 to bind to DNA containing an abasic site (Izumi et al.
However, an R177A mutant had enhanced APE activity [ 11 ] , as do mutations at N226 (Izumi et al.
Combining these mutations however greatly decreases substrate binding (Izumi et al.