Words similar to itk
Example sentences for: itk
How can you use “itk” in a sentence? Here are some example sentences to help you improve your vocabulary:
This subfamily includes six members: Btk, Tec, Itk/Tsk/Emt, Bmx/Emt, Dsrc29, and Rlk/Txk [ 3, 6, 7].
Recently, it has been found that the activation of Btk and Itk by Src family kinases is potentiated by and requires the activity of Phosphoinositide 3-kinase (PI3K), the products of which interact with the PH domains of Tec kinases [ 27, 28].
Data suggest that membrane association of Itk and Btk requires the interaction of their PH domains with products of PI3K, thereby facilitating phosphorylation by Src family kinases [ 27, 28].
It is also of note that we can reproducibly co-immunoprecipitate Rlk and Fyn, perhaps due to their association with RAFTs, whereas we have been unable to co-precipitate Itk with Src family kinases when co-expressed in 293T cells (data not shown), again demonstrating distinct properties of the Rlk protein compared to certain other members of the Btk family.
Rlk and Itk, may therefore function together in these TCR signaling events in a fashion similar to Btk in BCR signaling.
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