Example sentences for: itk

How can you use “itk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Data suggest that, for Itk, this membrane association specifically targets the protein to glycolipid enriched detergent-insoluble membrane microdomains known as "RAFTs" and that both this association and the activation of Itk requires the PH domain [ 29].

  • Moreover, Src family kinases have been found to phosphorylate and activate Btk, Itk, Tec and Rlk when co-expressed [ 16, 19, 21, 22, 23].

  • Recent data argue that Itk interacts directly with Slp-76 and Grb2 to participate in a LAT-nucleated T cell signaling complex involved in PLC-γ activation [ 5, 29].

  • Btk is the prototypical member of the Tec family of non-receptor protein tyrosine kinases (PTKs) that includes Bmx, Itk, Tec and Txk [ 2, 3].

  • Similar to Btk and Itk, we find that a conserved tyrosine in the activation loop of the Rlk kinase domain, Y420, mediates specificity for transphosphorylation of Rlk by Src family kinases.


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