Example sentences for: itk

How can you use “itk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, the association of Itk with RAFTs requires its PH domain and is dependent on the products of PI3K.

  • Indeed, in Jurkat cells, which are deficient in the inositol phophatase PTEN, Itk is constitutively associated with the membrane unless the cells are treated with inhibitors of PI3K or transfected with PTEN [ 36].

  • Recent data argue that Itk interacts directly with Slp-76 and Grb2 to participate in a LAT-nucleated T cell signaling complex involved in PLC-γ activation [ 5, 29].

  • Itk, a Tec family kinase that is predominantly expressed in T cells, is tyrosine phosphorylated and activated after stimulation of either the T cell receptor (TCR) or CD28 in T cell lines, and FcεRII in mast cells [ 12, 16, 17, 18].

  • Similar to Btk and Itk, we find that a conserved tyrosine in the activation loop of the Rlk kinase domain, Y420, mediates specificity for transphosphorylation of Rlk by Src family kinases.


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