Example sentences for: itk

How can you use “itk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This subfamily includes six members: Btk, Tec, Itk/Tsk/Emt, Bmx/Emt, Dsrc29, and Rlk/Txk [ 3, 6, 7].

  • Recently, it has been found that the activation of Btk and Itk by Src family kinases is potentiated by and requires the activity of Phosphoinositide 3-kinase (PI3K), the products of which interact with the PH domains of Tec kinases [ 27, 28].

  • Data suggest that membrane association of Itk and Btk requires the interaction of their PH domains with products of PI3K, thereby facilitating phosphorylation by Src family kinases [ 27, 28].

  • It is also of note that we can reproducibly co-immunoprecipitate Rlk and Fyn, perhaps due to their association with RAFTs, whereas we have been unable to co-precipitate Itk with Src family kinases when co-expressed in 293T cells (data not shown), again demonstrating distinct properties of the Rlk protein compared to certain other members of the Btk family.

  • Rlk and Itk, may therefore function together in these TCR signaling events in a fashion similar to Btk in BCR signaling.


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