Example sentences for: itk

How can you use “itk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Indeed, in Jurkat cells, which are deficient in the inositol phophatase PTEN, Itk is constitutively associated with the membrane unless the cells are treated with inhibitors of PI3K or transfected with PTEN [ 36].

  • Recent evidence from gene-targeted mice suggests that Rlk may synergize with Itk in signaling from the T cell receptor to activate phospholipase C-γ [ 20].

  • Recent data suggests that both Itk and Btk can also be associated with lipid RAFTs [ 29, 35].

  • It is also of note that we can reproducibly co-immunoprecipitate Rlk and Fyn, perhaps due to their association with RAFTs, whereas we have been unable to co-precipitate Itk with Src family kinases when co-expressed in 293T cells (data not shown), again demonstrating distinct properties of the Rlk protein compared to certain other members of the Btk family.

  • Furthermore, we have found that combined mutation of Rlk and Itk leads to profound defects in TCR signaling associated with impaired activation of PLC-γ [ 20].

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