Example sentences for: itams

How can you use “itams” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, despite constitutive Syk kinase activity, the ITAMs in the dominant-positive-expressing cells remain hypophosphorylated because kinases that are upstream of Syk and/or are Syk independent are not active in the absence of BCR crosslinking.

  • However, in light of the present model of signaling through the BCR, perhaps appropriate subcellular localization to the BCR protein complex and the ITAMs of CD79b (Igβ) is also required.

  • This is not surprising since the ITAMs in CD79, which are proposed to be docking sites for Syk, are unlikely to be phosphorylated in the absence of BCR stimulation since phosphorylation of these residues likely requires activation of Src family tyrosine kinases expressed in B cells.

  • In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .

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