Example sentences for: islet

How can you use “islet” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • βOgg1 is an alternatively spliced form of Ogg1 that contains a mitochondrial targeting signal in the C-terminal portion of the protein [ 41 ] . Specific upregulation of mitochondrial but not nuclear Ogg1 occurs during aging in rodents [ 42 ] . A specific increase of Ogg1 in islet cell mitochondria is consistent with the idea that increased β-cell mitochondrial oxidative metabolism due to hyperglycemia is a major factor behind the DNA damage.

  • In a summary of the 1977 Workshop on Pancreatic Islet Cell Transplantation in Diabetes, Lacy commented on the feasibility of “islet cell transplantation as a therapeutic approach [for] the possible prevention of the complications of diabetes in man” [12].

  • However, both GAD65 and GAD67 mRNA can be detected in the thymic medullary epithelial cells in mice [ 24 ] . Thus, despite thymic expression of GAD65 and GAD67 at the level of mRNA, NOD mice spontaneously develop autoreactivity to these islet (and brain) expressed proteins, and re-challenge of mice that have been immunized with peptides from GAD65 results in severe anaphylactic reactions.

  • First, our molecular analysis of differentiating IPCs showed that they remain distinct from mature pancreatic islet β-cells; in other words, the insulin + cells derived by our methods are not mature β-cells.

  • Current islet transplantation methods require an estimated 5 × 10 8 to 10 9 β-cells per recipient [45].


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