Words similar to irs-

Example sentences for: irs-

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Adaptor proteins that regulate tyrosine kinase signaling pathways fall into two major categories, those primarily with protein/protein interaction domains such as SH2, SH3, PTB, and PH domains, exemplified by the adaptor proteins c-crk, nck and grb-2, and those that are primarily tyrosine phosphorylated, exemplified by proteins such as Cas, Dok, IRS-1 and 2, Slp-76, LAT, TRIM or SIT.
Infection with the WT virus leads to a large increase in IGF-IR and IRS-1 tyrosine phosphorylation.
Infection with the MK virus eliminated the IGF-I stimulated phosphorylation of IRS-1 confirming that the expressed receptor was acting as a dominant negative to inhibit the endogenous receptors.
Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
To test the function of the virally encoded receptors, we measured IGF-I stimulated autophosphorylation of the IGF-IR and phosphorylation of IRS-1.