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Example sentences for: inviable
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As described previously in this paper and elsewhere [ 38 ] , the biology of fission yeast facilitates the identification of MII segregation defects that are difficult to detect in other organisms that terminate meiotic progression or produce inviable meiotic products as a consequence of defects in meiotic chromosome dynamics.
In addition, fission yeast mutants deficient in the enzymes that attach Ned8p, or in the ned8 gene itself, are inviable [ 5].
Since S. pombe contains only three chromosome pairs, aberrant assortment during one or both of the meiotic divisions can produce, by chance, a significant fraction of meiotic products that receive at least one copy of each chromosome and are hence viable [ 38 43 ] . Aberrant segregation can also produce nullisomic aneuploids (missing one or more chromosomes), polysomic aneuploids (having additional copies of individual chromosomes), and diploids [ 38 39 44 ] . In S. pombe the haploids and diploids are viable, nullisomic aneuploids are inviable, and disomic aneuploids tend to lose the extra chromosome or chromosomes and become haploid [ 45 ] . We therefore determined the frequencies of spore viability and meiotic diploidy as genetic measures of chromosome segregation errors.
Approximately 50% of the meiotic products from the rec12-117 and rec12-D15 (null) mutants were inviable (Figure 4A), indicating that about 50% of the products were nullisomic for one or more chromosomes.
Interestingly, the rec12-Y98F mutant produced a significantly higher frequency of inviable spores than the rec12-117 and rec12-D15 mutants (Figure 4A), suggesting that rec12-Y98F is a separation of function mutation.
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