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Example sentences for: inviable
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In addition, fission yeast mutants deficient in the enzymes that attach Ned8p, or in the ned8 gene itself, are inviable [ 5].
With a continuous fitness scale, apart from neutral and inviable sequences, we would have to keep track of slightly and strongly deleterious as well as advantageous sequences, and would consequently need a much more elaborate mathematical procedure to account for the contributions from these different fitness classes.
Since S. pombe contains only three chromosome pairs, aberrant assortment during one or both of the meiotic divisions can produce, by chance, a significant fraction of meiotic products that receive at least one copy of each chromosome and are hence viable [ 38 43 ] . Aberrant segregation can also produce nullisomic aneuploids (missing one or more chromosomes), polysomic aneuploids (having additional copies of individual chromosomes), and diploids [ 38 39 44 ] . In S. pombe the haploids and diploids are viable, nullisomic aneuploids are inviable, and disomic aneuploids tend to lose the extra chromosome or chromosomes and become haploid [ 45 ] . We therefore determined the frequencies of spore viability and meiotic diploidy as genetic measures of chromosome segregation errors.
Approximately 50% of the meiotic products from the rec12-117 and rec12-D15 (null) mutants were inviable (Figure 4A), indicating that about 50% of the products were nullisomic for one or more chromosomes.
Interestingly, the rec12-Y98F mutant produced a significantly higher frequency of inviable spores than the rec12-117 and rec12-D15 mutants (Figure 4A), suggesting that rec12-Y98F is a separation of function mutation.
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