Example sentences for: intranuclear

How can you use “intranuclear” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The independence of C/EBPα regulation of proliferation from its intranuclear localization may even be necessary since we have recently determined that pituitary cell differentiation is associated with the dispersal of C/EBPα from peri-centromeric heterochromatin by the pituitary-specific transcription factor Pit-1 (J.

  • Our preliminary observations indicate that some of the intranuclear inclusions containing Rab24(D123I) are immunoreactive for lamins, while those outside the nucleus are not (Fig.

  • However, there are many case reports describing patients with progressive neurodegenerative disorders of unknown etiology, collectively referred to as neuronal intranuclear inclusion disease [ 77 ] . While these may consist mainly of unidentified poly-Gln or poly-Ala disorders, the present study raises the possibility that some forms of this disease may arise through unexpected mechanisms, perhaps involving mutations in Rab24 or other poorly characterized members of the Rab GTPase family that mediate trafficking of misfolded proteins within autophagosomes and lysosomes.

  • [ 35 ] found that ATRIP Rad26and ATR Rad3also re-localize to a large number of intranuclear foci.

  • In a recent large-scale screen with 1739 yeast proteins used as bait [ 3 ] , midasin (YLR106p) was identified in the polypeptide sets that copurified with four bait proteins, ESS1p, RPT1p, YML029p and HRT1p, that function principally in RNA metabolism and in the regulation of proteasomes (which are mostly intranuclear in yeast [ 50 ] ). However, the interpretation of these proteomic data is clouded by the fact that no protein partners were identified in the complementary experiment in which midasin was itself used as bait.


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