Words similar to intranuclear
Example sentences for: intranuclear
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The gaps in the nuclear membrane were clearly visible in electron micrographs of cells with large numbers of intranuclear aggregates (Fig.
The independence of C/EBPα regulation of proliferation from its intranuclear localization may even be necessary since we have recently determined that pituitary cell differentiation is associated with the dispersal of C/EBPα from peri-centromeric heterochromatin by the pituitary-specific transcription factor Pit-1 (J.
However, there are many case reports describing patients with progressive neurodegenerative disorders of unknown etiology, collectively referred to as neuronal intranuclear inclusion disease [ 77 ] . While these may consist mainly of unidentified poly-Gln or poly-Ala disorders, the present study raises the possibility that some forms of this disease may arise through unexpected mechanisms, perhaps involving mutations in Rab24 or other poorly characterized members of the Rab GTPase family that mediate trafficking of misfolded proteins within autophagosomes and lysosomes.
Such constructs have been used successfully to define the functions of Rab1A and Rab1B [ 26 27 28 ] , Rab4 [ 29 ] , Rab5 [ 30 31 ] and Rab6 [ 32 ] . Unexpectedly, we found that expression of the mutant forms of Rab24 in cultured cells resulted in their accumulation in a striking array of insoluble intranuclear inclusions which disrupt the integrity of the nuclear envelope.
Our prior fluorescence microscopy studies showed that C/EBPα-GFP, GFP-C/EBPα, and antibody-stained C/EBPα [ 45 46 ] , concentrated at specific intranuclear domains in GHFT1-5 cells (see Fig.
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