Words similar to intranuclear
Example sentences for: intranuclear
How can you use “intranuclear” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, in some cells with larger and more numerous inclusions we observed discontinuities in the anti-lamin staining of the nuclear envelope and some co-localization of lamin with mycRab24(D123I) in the intranuclear aggregates.
Our preliminary observations indicate that some of the intranuclear inclusions containing Rab24(D123I) are immunoreactive for lamins, while those outside the nucleus are not (Fig.
[ 35 ] found that ATRIP Rad26and ATR Rad3also re-localize to a large number of intranuclear foci.
Such constructs have been used successfully to define the functions of Rab1A and Rab1B [ 26 27 28 ] , Rab4 [ 29 ] , Rab5 [ 30 31 ] and Rab6 [ 32 ] . Unexpectedly, we found that expression of the mutant forms of Rab24 in cultured cells resulted in their accumulation in a striking array of insoluble intranuclear inclusions which disrupt the integrity of the nuclear envelope.
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
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