Example sentences for: intranuclear

How can you use “intranuclear” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The independence of C/EBPα regulation of proliferation from its intranuclear localization may even be necessary since we have recently determined that pituitary cell differentiation is associated with the dispersal of C/EBPα from peri-centromeric heterochromatin by the pituitary-specific transcription factor Pit-1 (J.

  • Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.

  • The gaps in the nuclear membrane were clearly visible in electron micrographs of cells with large numbers of intranuclear aggregates (Fig.

  • Our prior fluorescence microscopy studies showed that C/EBPα-GFP, GFP-C/EBPα, and antibody-stained C/EBPα [ 45 46 ] , concentrated at specific intranuclear domains in GHFT1-5 cells (see Fig.

  • An immunofluorescence study was performed to determine whether or not the intranuclear Rab24(D123I) aggregates might sequester ubiquitin and Hsp70.


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