Example sentences for: intragenic

How can you use “intragenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The rec12-117 mutant was isolated in a genetic screen; the rec12-117 mutation reportedly confers a 100-fold or greater reduction of intragenic recombination and a 6-fold reduction of intergenic recombination [ 33 ] . To define more precisely the requirement for Rec12 in meiotic chromosome dynamics, we used gene replacement to generate a null ( rec12-D15 ) mutation and a mutation in the putative active site tyrosine ( rec12-Y98F ). We then determined the effects of these mutations upon intergenic (crossover) recombination within intervals of chromosomes

  • We have shown that polony technology is an improved method to study, and potentially diagnosis, cancer [ 22 ] . Specifically, polony technology was successfully applied to both detect intragenic mutations in well-defined mutational hotspots in key cancer genes as well as determine if loss of heterozygosity of these same genes had occurred.

  • Since we can not tell which of two neighboring genes is regulated by each of the 102 intergenic modules we predict, we are obliged to label 237 genes (adding the 33 genes with intragenic modules) as potentially patterned.

  • Direct sequencing of these products confirmed both of these contained Abcg8 rat cDNA sequences, but the larger product contained a 66 bp insertion, resulting in a predicted in-frame addition of 22 amino acids, between exons 2 and 3. To confirm that this insertion resulted from an alternatively spliced mRNA, we amplified and sequenced the intragenic region between exons 2 and 3 and identified a 66 bp exon (exon 2b), flanked by canonical splice-sites (see Table 2and Fig.

  • For example, Panc-1 was determined to possess only one copy of p53, which possessed an intragenic mutation in codon 273, and two copies of K- ras 2, one wildtype and one with an intragenic mutation in codon 12.


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