Words similar to intragenic
Example sentences for: intragenic
How can you use “intragenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The M6P/IGF2R is also mechanistically involved in the genesis of human cancer [ 6 20 21 22 23 24 ] . M6P/IGF2R loss of heterozygosity coupled with intragenic loss-of-function mutations in the remaining allele is a common event in human cancers [ 6 20 21 22 ] . Inheritance of a tandem repeat polymorphism in the 3' UTR of M6P/IGF2R furthermore predicts for enhanced susceptibility to oral cancer [ 25 ] . Moreover, tumor cell growth is inhibited when M6P/IGF2R expression is restored to normal while it is increased when gene expression is reduced [ 26 27 28 29 ] . The results of these mutational and functional studies clearly demonstrate that the M6P/IGF2R possesses the characteristics necessary to be classified as a tumor suppressor gene [ 30 ] .
Mating, meiosis, and preparation of free spores were as described [ 54 55 65 ] . Intergenic and intragenic recombinant frequencies were determined as described [ 38 65 ] . Because diploid spores could contain complementing markers and be mistaken for recombinants, we tested all spore colonies for diploidy by replica plating on complete media containing Phloxin-B (YEA-B).
We have shown that polony technology is an improved method to study, and potentially diagnosis, cancer [ 22 ] . Specifically, polony technology was successfully applied to both detect intragenic mutations in well-defined mutational hotspots in key cancer genes as well as determine if loss of heterozygosity of these same genes had occurred.
For example, Panc-1 was determined to possess only one copy of p53, which possessed an intragenic mutation in codon 273, and two copies of K- ras 2, one wildtype and one with an intragenic mutation in codon 12.
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