Words similar to intra-testicular
Example sentences for: intra-testicular
How can you use “intra-testicular” in a sentence? Here are some example sentences to help you improve your vocabulary:
Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.
The increased concentration of ABP present in the testes of TG mice (see Joseph et al . [ 25 ] ) will chronically reduce the concentration of intra-testicular free T available for interaction with androgen receptor (AR) and other molecular targets.
[ 26 ] ). This would also indicate that the pre-pubertal wave of apoptosis is regulated, at least in part, by T. Indeed, it has been reported that experimental reduction in the levels of intra-testicular T leads to the activation of caspase-3 [ 56 ] and thereby to an increase in germ cell apoptosis [ 57 58 ] . The roles of other apoptosis-regulating proteins, such as the Fas/Fas ligand system [ 47 59 60 ] , the Bcl-2 family of proteins [ 61 62 ] , and several "inhibitor of apoptosis" proteins (IAP) are also likely to play a role in germ cell death and survival [ 63 64 65 ] .
However, at this point it is not clear whether ABP regulates this apoptotic wave by direct action on germ cells or indirectly, by reducing the intra-testicular concentrations of free (bioavailable) T. The known biochemical properties and actions of ABP make the second mechanism more likely (see Jeyaraj et al.
The presence of increased numbers of apoptotic germ cells in ABP-TG mice compared to WT controls on Days 21, 30 and 60 suggests that this age group is more vulnerable than adult animals to increased levels of intra-testicular ABP.
Loading...