Example sentences for: intra-testicular

How can you use “intra-testicular” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The increased concentration of ABP present in the testes of TG mice (see Joseph et al . [ 25 ] ) will chronically reduce the concentration of intra-testicular free T available for interaction with androgen receptor (AR) and other molecular targets.

  • However, at this point it is not clear whether ABP regulates this apoptotic wave by direct action on germ cells or indirectly, by reducing the intra-testicular concentrations of free (bioavailable) T. The known biochemical properties and actions of ABP make the second mechanism more likely (see Jeyaraj et al.

  • [ 26 ] ). This would also indicate that the pre-pubertal wave of apoptosis is regulated, at least in part, by T. Indeed, it has been reported that experimental reduction in the levels of intra-testicular T leads to the activation of caspase-3 [ 56 ] and thereby to an increase in germ cell apoptosis [ 57 58 ] . The roles of other apoptosis-regulating proteins, such as the Fas/Fas ligand system [ 47 59 60 ] , the Bcl-2 family of proteins [ 61 62 ] , and several "inhibitor of apoptosis" proteins (IAP) are also likely to play a role in germ cell death and survival [ 63 64 65 ] .

  • The presence of increased numbers of apoptotic germ cells in ABP-TG mice compared to WT controls on Days 21, 30 and 60 suggests that this age group is more vulnerable than adult animals to increased levels of intra-testicular ABP.

  • Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.

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