Words similar to internalization
Example sentences for: internalization
How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:
To determine the effect of the ribozyme on the functional activity of M6P/IGF2R, the binding and internalization of exogenous 125I-IGF-II was measured in cells infected with Ad-GFP/Rz-IGF2R or Ad-GFP.
The common reference to “finally the sleeping giant awakens” when conferring on Mexican American social-political issues is made often by educated and acculturated Chicanos, manifesting an internalization of an image imposed from outside the Mexican culture.
The importance of bacterial internalization, however, could not be addressed in these experiments.
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
Our data presented here show clearly that without any kind of stimulation the endogenously released enkephalins (even protected by enkephalinase inhibitors) were not able to induced an internalization of the δ-opioid receptors in the rat spinal cord.
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