Example sentences for: internalization

How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Such internalization events appear to contribute substantially to the infectivity enhancement by virus-microbead conjugates.

  • This increase in fluorescence is not due to the internalization of oxidized dye since no oxidation of the OxyBURST Green H 2 HFF BSA was observed in the labeling medium during the loading procedure (data not shown).

  • The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .

  • More recently, in vitro studies carried out on δ-opioid receptors, showed that following a rapid internalization in response to an agonist stimulation, the endocytosed receptors were recycled back to the plasma membrane ( 33).

  • However, no nociceptive stimulation was applied in our protocol, and we therefore can not exclude the possibility that insufficient enkephalin was released to provoke the internalization of the δ-opioid receptor.


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