Example sentences for: internalization

How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, no nociceptive stimulation was applied in our protocol, and we therefore can not exclude the possibility that insufficient enkephalin was released to provoke the internalization of the δ-opioid receptor.

  • Expression of the ribozyme targeted against the M6P/IGF2 receptor in MCF-7 cells resulted in down-regulation of M6P/IGF2R expression, as measured by RT-PCR, and M6P/IGF2R function, indicated by a decrease in internalization of 125I-IGF-II, and β-glucuronidase binding and endocytosis.

  • 4A, cells infected with Ad-GFP/Rz-IGF2R had a corresponding reduction of ~40% in 125I-IGF-II internalization when compared with control cells (infected with Ad-GFP).

  • These findings raise two related questions: 1) can δ-opioid receptors be internalized in vivo by the same agonist-induced endocytosis observed in vitro ? and if this is the case, 2) does the internalization process have the same kinetics reported from in vitro studies?

  • Another hypothesis poses the question of whether the internalization process is agonist-selective.


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