Words similar to internalization
Example sentences for: internalization
How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:
These findings raise two related questions: 1) can δ-opioid receptors be internalized in vivo by the same agonist-induced endocytosis observed in vitro ? and if this is the case, 2) does the internalization process have the same kinetics reported from in vitro studies?
It seems that the internalization/recycling process is a necessary step in the resensitization of the receptor.
There are three subtypes of the alpha-2 adrenergic receptor: alpha-2A; alpha-2B; and alpha-2C [ 15 ] . The human alpha-2A subtype undergoes phosphorylation and short-term desensitization [ 11 12 ] , whereas the human alpha-2C subtype is not phosphorylated [ 16 ] and does not desensitize [ 11 ] . The human alpha-2C subtype, however, does undergo arrestin-dependent internalization [ 17 ] . Many studies [ 11 18 ] , including those from our laboratory [ 10 19 20 ] , have demonstrated agonist-induced down-regulation of alpha-2 receptors, although much less is known about the specific mechanisms for down-regulation as compared to the beta-2 receptor.
For example, Lawrence and Ochman [ 4 ] hypothesized that the recently transferred genes were adapted to the genomic context of other distant species; however, our results would suggest either that the donor genomes are always more A+T rich than the acceptor genomes or that there is a bias toward the internalization of A+T-rich exogenous DNA in the genome.
The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.
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