Words similar to internalization
Example sentences for: internalization
How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:
The common reference to “finally the sleeping giant awakens” when conferring on Mexican American social-political issues is made often by educated and acculturated Chicanos, manifesting an internalization of an image imposed from outside the Mexican culture.
A more recent study carried out in rat spinal cord slices found a possible internalization of μ-opioid receptor after stimulation by DAMGO ( 30).
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) maps to chromosome location 6q25-27 [ 14 ] ; a chromosomal region predicted to contain a head and neck tumor suppressor gene [ 10 11 ] . It encodes for a receptor that functions in intracellular lysosomal enzyme trafficking, transforming growth factor beta activation, and IGF2 degradation (reviewed in [ 15 16 ] ). Granzyme B internalization by the M6P/IGF2R is also required for cytotoxic T cells to induce apoptosis in cells targeted for death, resulting in this receptor being referred to as a "death receptor" [ 17 ] . Elevated IGF2 levels during murine development arising from M6P/IGF2R deficiency result in cardiac abnormalities, cleft palate, fetal overgrowth and perinatal lethality [ 15 18 ] . Furthermore, large offspring syndrome frequently observed in cloned animals is associated with epigenetic changes in gene regulation and decreased M6P/IGF2R expression [ 19 ] . Thus, the M6P/IGF2R plays a crucial role in regulating mammalian fetal growth and development.
Sequentially mutating each of the four serines to alanine decreased the phosphorylation of the receptor by approximately 25% for each serine, and mutating either the first two or the last two serines to alanines prevented agonist-induced desensitization, but not agonist-induced sequestration/internalization [ 12 ] . The influence of mutations in this motif on down-regulation has not been investigated.
Our findings demonstrate that dermenkephalin, after in vivo administration, can induce an internalization of the δ-opioid receptor at the level of the spinal cord.
Loading...