Example sentences for: internalization

How can you use “internalization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Prolonged or repeated agonist stimulation of G protein-coupled receptors frequently causes a reduction in the response to the agonist [ 1 ] . Short-term agonist exposure results in desensitization that is characterized by a rapid (minutes) and reversible uncoupling of the receptor from the G protein followed by sequestration and/or internalization of receptors from the cell surface.

  • 4A, cells infected with Ad-GFP/Rz-IGF2R had a corresponding reduction of ~40% in 125I-IGF-II internalization when compared with control cells (infected with Ad-GFP).

  • To determine the effect of the ribozyme on the functional activity of M6P/IGF2R, the binding and internalization of exogenous 125I-IGF-II was measured in cells infected with Ad-GFP/Rz-IGF2R or Ad-GFP.

  • Most importantly, however, the lethal nature of an M6P/IGF2R-null phenotype is reversed in an IGF-II-null background [ 34 ] . Although we did not measure extracellular levels of IGF-II, our results show that ribozyme-mediated down-regulation of M6P/IGF2R leads to a decrease in IGF-II internalization, supporting the above possibility.

  • The internalization of receptor-agonist ligand complex has been detected with similar kinetics to those of down-regulation ( 8, 9).


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