Example sentences for: inter-patient

How can you use “inter-patient” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To analyze the impact of intra-patient variability (tissue heterogeneity), inter-patient variability (polymorphic noise in outbred populations), and the effect of sample mixing on the sensitivity of detection of gene expression differences between patient groups, we conducted a series of individual and mixed profiling (Table 1).

  • The above findings suggested that both intra-patient variability (tissue heterogeneity) and inter-patient variability (polymorphic noise) had major effects on the expression profiles.

  • Typically, multiple arrays are compared, with those gene expression changes showing the most consistent fold changes prioritized, although other methods have been reported [ 13 22 26 27 ] . To study inter-patient variability, we defined the gene expression changes surviving four pairwise comparisons with mixed control samples, as we have previously described [ 23 ] . Briefly, four comparisons were done by Affymetrix software (eg.

  • We have recently reported generation of expression profiling results using mixed patient samples [ 23 ] . Our hypothesis was that mixing of RNA samples from multiple regions of muscle biopsies, and from multiple patients matched for most variables (disease, age, sex), would effectively normalize both intra-patient variability (tissue heterogeneity), and inter-patient variability (SNP noise; e.g. normal human polymorphic variation unrelated to the primary defect).

  • Specifically, we studied the correlation coefficients of profiles considering the following variables: 1. variation due to probe production (same RNA); 2. variation due to the microarray itself (same cRNA on different GeneChips); 3. tissue heterogeneity (different regions of the same muscle biopsy); 4. inter-patient variability (SNP noise); 5. diagnosis (underlying pathological variable); and 6. patient age.


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