Example sentences for: insufficiency

How can you use “insufficiency” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Systemic sclerosis (SSc) is a connective-tissue disease characterized by progressive thickening of the dermis, often accompanied by insufficiency of internal organs, such as the lungs, heart, or kidneys [ 1].

  • Unfortunately, cortisol levels and adrenocorticotrophic hormone (ACTH) response was not routinely measured in patients with infection, and adrenal insufficiency may have been underestimated in this group.

  • · Sepsis can cause occult adrenal insufficiency in the presence of normal or even elevated serum cortisol concentrations.

  • Aggressive methods of decreasing oxygen consumption, such as therapeutic musculoskeletal blockade, are used for patients with marginal oxygen delivery associated with cardiac and respiratory insufficiency.

  • M6P/IGF2R is normally imprinted in mice with only the maternal copy of the gene being expressed [ 41 ] . In contrast, both copies of the M6P/IGF2R are expressed in humans because genomic imprinting at this locus was lost in the primate lineage approximately 75 million years ago [ 42 ] . Importantly, restoration of biallelic M6P/IGF2R expression in mice results in a marked reduction in offspring weight late in embryonic development that persists into adulthood [ 43 ] . This demonstrates that M6P/IGF2R allelic loss or haploid insufficiency markedly enhances cell proliferation and/or survival during fetal development.


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