Words similar to insufficiency
Example sentences for: insufficiency
How can you use “insufficiency” in a sentence? Here are some example sentences to help you improve your vocabulary:
Haploid insufficiency for tumor suppressor genes, such as Nf2 , p27 Kip 1, p53 , Ptch , Pten and TGFβ , is known to promote tumor formation (reviewed in [ 44 45 ] ). Yamada et al.
Serum cortisol level determination was performed on all patients receiving exogenous corticosteroids or in patients with known risk factors for adrenal insufficiency.
Observed initial findings that related to disseminated intravas-cular coagulation, respiratory insufficiency, altered mental status, and renal, cardiac, and liver failure were noted [ 26, 27].
M6P/IGF2R is normally imprinted in mice with only the maternal copy of the gene being expressed [ 41 ] . In contrast, both copies of the M6P/IGF2R are expressed in humans because genomic imprinting at this locus was lost in the primate lineage approximately 75 million years ago [ 42 ] . Importantly, restoration of biallelic M6P/IGF2R expression in mice results in a marked reduction in offspring weight late in embryonic development that persists into adulthood [ 43 ] . This demonstrates that M6P/IGF2R allelic loss or haploid insufficiency markedly enhances cell proliferation and/or survival during fetal development.
Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
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