Example sentences for: in-frame

How can you use “in-frame” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To generate Rab24 fusions with Enhanced Green Fluorescent Protein (EGFP), cDNAs encoding full-length Rab24(wt) or Rab24(D123I), or the Rab24 C-terminal hypervariable domain (residues 166-203) were generated with flanking KpnI and BamHI sites and subcloned into pEGFP-C1 (Clontech Inc., Palo Alto, CA) so that the Rab inserts were in-frame with a 5' EGFP coding sequence.

  • Several mutations have been identified in the context of epidermal growth factor receptor (EGFR) in patients with NSCLC that are associated with clinical response to the small-molecule EGFR inhibitors gefitinib (Iressa) or erlotinib (Tarceva) [7,8,9], including in-frame deletions such as del L747–E749;A750P in exon 19, or L858R in exon 21.

  • The actA internal in-frame deletion mutant (DP-L1942) [ 30], which cannot initiate the polymerization of actin, was used to assess transcriptional responses specific to the motility phase of infection.

  • This created an open reading frame of 1,083 base pairs with an in-frame TGA stop codon.

  • The longest BTBD1 cDNA clone obtained from two-hybrid screening (3196 bp) contains an ORF that encodes a 482 aa protein starting with an ATG that is preceded by an in-frame stop codon.


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