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Example sentences for: improvementin
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The data presented suggest that attenuation of apoptosis mayunderlie the beneficial effect of β-blockade on ventricular function,and that the inhibition of apoptosis can possibly lead to improvementin ventricular function.
In vivo contractile performance of the heart was assessed bythe determination of fractional shortening of the left ventricle.As shown in Table 1and Figure 1, fractional shortening was increasedby 32 and 45% in DCM 1 and DCM 20 animals, respectively,compared to non-treated DCM animals (DCM 0 ). Comparedwith baseline values at the time of randomization, the improvementin fractional shortening was of 57% in DCM 1 and 65% inDCM 20 . Associated with improved cardiac function wasa reduction in the incidence of apoptotic nuclei (see below).
Both in animal and human studies of heart failure, β-adrenergicblockade intervention appears to have beneficial effects on cardiacmyocyte function [ 1 23 24 ] . Of particularimportance, studies using carvedilol have shown remarkable improvementsin cardiac performance [ 12 13 15 16 ] andreduction in mortality in humans [ 17 ] .We have previously shown that propranolol, a nonselective β-blocker,is cardioprotective and prevents the development of heart failurein turkeys when given concurrently with furazolidone [ 21 ] . Similarly, carteolol, a nonselective β-blocker,resulted in improvement in ejection fraction, reduction in ventricularvolumes, an increase in developed pressure as well as an increasein rate of survival in our turkey model [ 18 ] . Improvementin cardiac function was associated with cellular remodeling of cardiacmyocytes.