Example sentences for: impinge

How can you use “impinge” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although deregulated HER-2 / neu activity can strongly stimulate cytoplasmic signalling pathways, which in turn impinge on c- myc at multiple levels causing its deregulated expression [ 46 ] , this scenario does not appear to be active in NNBC because the recurrence rate of 22 c- myc and HER-2 / neu coamplified patients was only 9%.

  • Markets operate on felt signals, and it is taking too long for the signal that there is an excess of doctors (especially very high-priced specialists) to impinge upon the supply-producing parts of the system.

  • Although some donkey carts and bicycles occasionally impinge on the tranquillity of the main street, the townsfolk have plenty of time to stand around and gossip.

  • The fact that you are an office of only 10 people, and Lothario now finds himself too busy for some tasks, means the involvement has begun to impinge on the workplace.

  • First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.


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