Words similar to immunodominant
Example sentences for: immunodominant
How can you use “immunodominant” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, administration of GAD65 to young NOD mice has been shown to prevent insulitis and diabetes [ 8 9 ] , apparently via induction of CD4+ regulatory T cells with a T H 2 phenotype [ 10 ] . Similarly, treatment with immunodominant peptides of myelin can prevent or reverse experimental autoimmune encephalomyelitis (EAE), a T H 1-associated inducible "autoimmune" disorder that is widely used as a model for human multiple sclerosis [ 11 12 13 ] .
It was of interest that the unmodified protease induces antigen-specific IgG in the absence of detectable immunodominant T cell epitopes.
Thus, the incidence of anaphylactic shock in mice immunized and challenged with PD peptides was significantly lower than that in mice immunized and challenged with immunodominant G7 peptides (P = 0.0058 by Fisher's exact test).
Anaphylaxis also developed in some NOD mice that had been immunized and challenged with preparations of PD peptides (that are not immunodominant in NOD mice), although both the drop in body temperature and the death rate in these mice were significantly less than those observed in the mice immunized and challenged with G7 peptides.
In the present study, we show that anti-peptide autoantibodies and fatal anaphylactic reactions can be elicited by immunodominant GAD65 peptides in NOD mice that have been injected with these peptides intraperitoneally in incomplete Freund's adjuvant (IFA), as part of an attempt to induce "tolerance" and prevent the spontaneous development of T1DM.
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