Words similar to immunodominant
Example sentences for: immunodominant
How can you use “immunodominant” in a sentence? Here are some example sentences to help you improve your vocabulary:
Anaphylaxis also developed in some NOD mice that had been immunized and challenged with preparations of PD peptides (that are not immunodominant in NOD mice), although both the drop in body temperature and the death rate in these mice were significantly less than those observed in the mice immunized and challenged with G7 peptides.
injections of the immunodominant G7 peptides (GAD 206-226/217-236/286-300) or of the additional GAD65 peptides identified in NOD.PD mice (I-A NOD/PD) (GAD 333-345/K458-470R) in IFA [ 5 ] . As noted in the background section, PD peptides are not immunodominant in NOD mice.
However, in the thymus a splice variant results in the lack of thymic expression of an immunodominant peptide.
For example, administration of GAD65 to young NOD mice has been shown to prevent insulitis and diabetes [ 8 9 ] , apparently via induction of CD4+ regulatory T cells with a T H 2 phenotype [ 10 ] . Similarly, treatment with immunodominant peptides of myelin can prevent or reverse experimental autoimmune encephalomyelitis (EAE), a T H 1-associated inducible "autoimmune" disorder that is widely used as a model for human multiple sclerosis [ 11 12 13 ] .
Indeed, we originally included the PD-immunized group because PD peptides are the immunodominant epitopes that are presented in transgenic NOD.PD mice that do not get diabetes [ 4 5 ] . Because of their unknown, and potentially even protective, role in the diabetes-resistant NOD.PD strain, we felt that it was important to assess whether, through a peptide therapy regimen, PD peptides might be able to protect against diabetes by shifting T H 1 to T H 2 responses in NOD mice.
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