Words similar to immunodominant
Example sentences for: immunodominant
How can you use “immunodominant” in a sentence? Here are some example sentences to help you improve your vocabulary:
injections of the immunodominant G7 peptides (GAD 206-226/217-236/286-300) or of the additional GAD65 peptides identified in NOD.PD mice (I-A NOD/PD) (GAD 333-345/K458-470R) in IFA [ 5 ] . As noted in the background section, PD peptides are not immunodominant in NOD mice.
Indeed, we originally included the PD-immunized group because PD peptides are the immunodominant epitopes that are presented in transgenic NOD.PD mice that do not get diabetes [ 4 5 ] . Because of their unknown, and potentially even protective, role in the diabetes-resistant NOD.PD strain, we felt that it was important to assess whether, through a peptide therapy regimen, PD peptides might be able to protect against diabetes by shifting T H 1 to T H 2 responses in NOD mice.
Thus, the incidence of anaphylactic shock in mice immunized and challenged with PD peptides was significantly lower than that in mice immunized and challenged with immunodominant G7 peptides (P = 0.0058 by Fisher's exact test).
In accord with these results, immunization of the NOD mice with PD peptides produced a less robust specific IgG1 antibody response than did immunization with the immunodominant G7 peptides (see below).
Anaphylaxis also developed in some NOD mice that had been immunized and challenged with preparations of PD peptides (that are not immunodominant in NOD mice), although both the drop in body temperature and the death rate in these mice were significantly less than those observed in the mice immunized and challenged with G7 peptides.
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