Example sentences for: ikb

How can you use “ikb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Mefloquine induced changes in the expression of three genes, GADD153, IkB and cJun.

  • However, this is not the case for GADD153 and IkB.

  • Mefloquine induced changes in the expression of genes encoding cJun, IkB and the ER stress response protein GADD153.

  • The eleven genes with the lowest (array) P -values are presented in Table 2. The upregulation by mefloquine of transcripts encoding the transcription factors cJun and IkappaB (IkB) and the ER stress protein GADD153 were confirmed by RT-PCR (Table 2, Figure 2).

  • Two highly conserved responses are observed under conditions of endoplasmic reticulum (ER) stress; the ER overload and unfolded protein responses [ 24 25 ] . The unfolded protein response is characterized by generalized suppression of protein synthesis and the specific induction of ER-resident proteins and GADD153 [ 24 ] . The transcription factor nuclear factor kB is activated during the ER overload response, leading to the downstream induction of pro-inflammatory proteins [ 25 ] . Therefore, the transcriptional modulation of GADD153 and IkB by mefloquine suggests that the ER might be a target of the drug.

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