Words similar to ii-iii
Example sentences for: ii-iii
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Hence, a premature stop codon in the II-III loop upstream of M701 may not necessarily cause a loss of DHPR function because in these cases, function would be recovered by complementation between protein fragments expressed by the same cDNA.
Earlier studies in the voltage-gated Na +channel had shown that pore function was not compromised when the II-III linker or III-IV linker was cut and the two fragments were coexpressed each in a separate vector [ 37 ] . We would thus conclude that in the case of the Ca 2+channel, an intact II-III loop is essential for this function since neither fs-α 1S nor the combined expression of the two truncated fragments (not shown) was able to rescue Ca 2+current.
This region was identified using chimeras of α 1S and α 1C [ 16 ] . Since Csk53 is present in α 1S Δ1-700 and was detected by the II-III loop antibody which is directed against the center portion of Csk53 [ 34 ] , the participation of this domain in the EC cannot be ruled-out.
The present studies show EC coupling recovery by a frame-shift mutant of α 1S due to protein-protein complementation of the N-terminal and C-terminal halves of α 1S . The N-terminal half houses repeats I and II with the adjoining cytosolic loop and the C-terminal half houses most of the II-III loop, along with repeats III and IV with the adjoining loop.
The C-terminal fragment was identified with SKI, a rabbit polyclonal antibody against the II-III loop of α 1S (Ala739-Ile752) previously characterized [ 34 ] . Cells were scrapped from tissue cultures dishes with cold PBS plus protease inhibitors and spun in a cold table-top centrifuge.
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