Words similar to igβ

Example sentences for: igβ

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In immature B cells, activation through the BCR induces either a state of unresponsiveness, termed anergy, or death by apoptosis, depending on the physical nature and concentration of the antigen [ 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ] . In some B cell lymphomas, activation through the BCR can induce cell cycle arrest and apoptosis in vitro and tumor dormancy in vivo [ 19 26 27 28 ] . The core of the multi-subunit BCR is membrane-bound immunoglobulin (mIg), which is non-covalently associated with two co-receptor molecules, CD79a (Igα) and CD79b (Igβ), products of the mb-1 and B29 genes [ 29 30 ] . The biochemical changes induced by engagement of the BCR are extensive and include an increase in tyrosine phosphorylation of several intracellular proteins, hydrolysis of membrane phospholipids, fluxes in the concentration of intracellular free Ca 2+, activation of several serine/threonine kinases including components of the MAP kinase pathway, and changes in the activities of a panel of transcription factors.
However, in light of the present model of signaling through the BCR, perhaps appropriate subcellular localization to the BCR protein complex and the ITAMs of CD79b (Igβ) is also required.