Words similar to iggsd
Example sentences for: iggsd
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Further, this implies that putative Ch6p alleles associated with CVID or IgGSD susceptibility occur on many HLA haplotypes that are common in Caucasians in central Alabama [ 10 ] and in Caucasians from a large national bone marrow donor program [ 14 ] . The present observations also confirm and extend the reports of association of HLA haplotype A*01-B*08 (or an extended haplotype containing A*01 and B*08) with heritable forms of immunoglobulin deficiency demonstrated in family-based analyses [ 3 6 19 20 21 22 ] . It is likely that a candidate gene(s) for CVID or IgGSD exists in the HLA class II region, [ 6 19 20 21 22 23 ] . Because the class II region is closer to the HLA-B locus than to the HLA-A locus, it is plausible that candidate gene(s) for CVID or IgGSD in the class II region are in greater linkage disequilibrium with HLA-B than HLA-A.
Taken together, these observations could explain the occurrence of CVID or IgGSD and hemochromatosis due to HFE C282Y homozygosity in some of the present index patients [ 26 ] and account for the occurrence of IgA deficiency and hemochromatosis in different members of the same family [ 27 ] .
We also evaluated the relationships of HLA-A and -B phenotype frequencies and haplotypes with phenotypes defined by serum immunoglobulin concentrations, and we estimated the combined frequency of CVID and IgGSD in central Alabama based upon the occurrence of these disorders in the spouses of the present index cases.
In addition, the haplotypes A*01-B*08 and A*02-B*44 significantly associated with CVID and IgGSD in the present study are common in both hemochromatosis probands homozygous for HFE C282Y and control subjects in Alabama [ [ 10 ] ; present study].
There were approximately equal fractions of index patients with CVID and IgGSD, respectively (Table 1).
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