Words similar to ifn-γ
Example sentences for: ifn-γ
How can you use “ifn-γ” in a sentence? Here are some example sentences to help you improve your vocabulary:
The retention of Jak-STAT1 signaling in RANKL-stimulated pre-osteoclasts is intriguing, given their demonstrated insensitivity to IFN-γ.
The resolution of this issue is further clouded by the apparent contradictory findings that IFN-γ is an extremely potent anti-osteoclastogenic factor [ 38 ] but it can be found at high levels in sites of osteolysis [ 39 ] . To reconcile this controversy we performed a series of experiments aimed at understanding how IFN-γ could induce either bactericidal effects via macrophage activation or osteoclastic bone resorption, by influencing the same progenitor cell in the same bone environment.
We therefore were interested in finding out how IFN-γ and IL-4 regulate isotype expression of the PG-specific antibodies and if an autoantibody isotype contributes to the severity of disease.
Consistent with our prior results, concomitant treatment of IFN-γ and RANKL showed dominance of the IFN-γ upregulation, while pretreatment with RANKL for 2 days showed impaired upregulation.
Since there is no evidence that IL-4 directly inhibits IgG2a transcription in B cells, this cytokine very likely suppresses the IFN-γ response, either directly or indirectly.
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