Example sentences for: ifn-γ

How can you use “ifn-γ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The retention of Jak-STAT1 signaling in RANKL-stimulated pre-osteoclasts is intriguing, given their demonstrated insensitivity to IFN-γ.

  • The resolution of this issue is further clouded by the apparent contradictory findings that IFN-γ is an extremely potent anti-osteoclastogenic factor [ 38 ] but it can be found at high levels in sites of osteolysis [ 39 ] . To reconcile this controversy we performed a series of experiments aimed at understanding how IFN-γ could induce either bactericidal effects via macrophage activation or osteoclastic bone resorption, by influencing the same progenitor cell in the same bone environment.

  • We therefore were interested in finding out how IFN-γ and IL-4 regulate isotype expression of the PG-specific antibodies and if an autoantibody isotype contributes to the severity of disease.

  • Consistent with our prior results, concomitant treatment of IFN-γ and RANKL showed dominance of the IFN-γ upregulation, while pretreatment with RANKL for 2 days showed impaired upregulation.

  • Since there is no evidence that IL-4 directly inhibits IgG2a transcription in B cells, this cytokine very likely suppresses the IFN-γ response, either directly or indirectly.


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