Words similar to hypothalamic

Example sentences for: hypothalamic

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These data are also consistent with the observation that in streptozotocin-induced diabetic rats, replacement of insulin is not sufficient to normalize elevated serum corticosterone or the elevated hypothalamic AGRP mRNA while it does partially normalize plasma leptin and hypothalamic POMC mRNA [ 17 ] .
Taken together, these data suggest that elevated glucocorticoids are sufficient to drive the increase in hypothalamic AGRP mRNA during fasting and diabetes but not the reduction in POMC mRNA.
Although a reduction in plasma leptin plays an important role in mediating neuroendocrine responses to fasting [ 6 ] and diabetes [ 17 ] , we have previously demonstrated that fasting can regulate hypothalamic melanocortin tone independently of both leptin and insulin [ 5 ] . The present studies suggest that corticosterone may play a role in mediating these leptin-independent effects.
Effects of diet and adrenalectomy on hypothalamic POMC mRNA
In the present study, we observed that adrenalectomy did indeed lead to a remarkable enhancement of hypothalamic POMC mRNA tone in mice made obese on a high-fat diet; surprisingly, however, adrenalectomy did not reverse diet-induced obesity.