Words similar to hypothalamic

Example sentences for: hypothalamic

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Therefore hypothalamic AGRP and POMC mRNAs were both induced by the glucocorticoid implant, whereas the NPY mRNA was not significantly influenced.
Fasting decreased hypothalamic POMC mRNA as expected in the sham-operated fasted group, but fasting had no effect on POMC mRNA in the adrenalectomized animals (Fig.
Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.
Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
In several respects the conclusions from this study are similar to the present study (for example, corticoisterone implants increased hypothalamic AGRP and POMC mRNA, and adrenalectomy blocked the effect of fasting on hypothalamic POMC mRNA).