Words similar to human-specific
Example sentences for: human-specific
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This is the first time that copy number changes among apes have been assayed for the vast majority of human genes, and we can expect that the biological consequences of the 140 human-specific copy number changes identified in this study will be heavily investigated over the coming years.
Although the CHRNA7 duplication had, on the basis of sequence identity, previously been postulated to be human-specific, the location of this duplicon within the 600 kb interval associated with the pericentric inversion in chimpanzee necessitated determination of the copy number of CHRNA7 within the chimpanzee genome [ 17 ] . First, chimpanzee BAC library hybridizations (8.
3 and the fact the CHRNA7 duplication appeared polymorphic in the human population [ 17 ] . This hypothesis deserved consideration in this study, as the site of duplication of the CHRNA7 locus in the human genome may correspond to the pericentric inversion breakpoint, and the high sequence homology noted between the donor and duplicated CHRNA7 loci does not establish the human-specificity of the CHRNA7 duplication, as gene conversion may also maintain high sequence homology of duplicated segments [ 26 27 ] . Thus, we tested the chimpanzee genome by Southern genomic analysis for the presence of the CHRNA7 duplication which revealed this duplication is most likely human-specific and therefore did not contribute to the pericentric inversion in chimpanzee (Figure 5).
Alternatively, this site, which contains a recent human-specific segmental duplication of the CHRNA7 locus, may be a preferential site of breakage, which allowed the pericentric inversion to occur.
In Riley et al . [ 17 ] , the authors theorize that the duplication of the CHRNA7 locus is a human-specific event because of the high sequence homology of the duplicated segment to the donor segment in 15q13.
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