Words similar to human-mouse-rat
Example sentences for: human-mouse-rat
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The total number of orthologous protein sets that show evidence of accelerated evolution suggestive of functional diversification is between 0.76% and 1% of the total number of such sets analyzed for each species (Chlamydiaceae = 7/703, Pyrococcus = 11/1305, human-mouse-rat= 16/2112).
Subsequent to the construction of human-mouse-rat COGs and phylogenetic trees, the 'triplet test' [ 17] was used to further ensure that the COGs of size 3 contained only orthologs.
Alignments that resulted in any branch lengths (based on the corrected gamma distance, see below) longer than 2 in the case of the Chlamydiaceae and Pyrococcus species groups or longer than 1 in the case of the human-mouse-rat species group were visually inspected and adjusted manually.
For the bacterial and archaeal species groups, the vast majority of these comparisons were inconclusive because the evolutionary distance between phylogenetic partitions resulted in a saturation of K s . The more closely related human-mouse-rat group did not show saturation of K s . Comparisons of K s and K a for functionally diversified mammalian protein sets did not reveal any cases with K a > K s . This is probably due to the fact that, if directional selection led to the acceleration of the amino-acid substitution rate in these proteins, it acted in an episodic manner [ 6, 7] and on a minority of residues against a constant background of purifying selection [ 8, 9].