Words similar to human-mouse-rat
Example sentences for: human-mouse-rat
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For the bacterial and archaeal species groups, the vast majority of these comparisons were inconclusive because the evolutionary distance between phylogenetic partitions resulted in a saturation of K s . The more closely related human-mouse-rat group did not show saturation of K s . Comparisons of K s and K a for functionally diversified mammalian protein sets did not reveal any cases with K a > K s . This is probably due to the fact that, if directional selection led to the acceleration of the amino-acid substitution rate in these proteins, it acted in an episodic manner [ 6, 7] and on a minority of residues against a constant background of purifying selection [ 8, 9].
Alignments that resulted in any branch lengths (based on the corrected gamma distance, see below) longer than 2 in the case of the Chlamydiaceae and Pyrococcus species groups or longer than 1 in the case of the human-mouse-rat species group were visually inspected and adjusted manually.
Subsequent to the construction of human-mouse-rat COGs and phylogenetic trees, the 'triplet test' [ 17] was used to further ensure that the COGs of size 3 contained only orthologs.
The total number of orthologous protein sets that show evidence of accelerated evolution suggestive of functional diversification is between 0.76% and 1% of the total number of such sets analyzed for each species (Chlamydiaceae = 7/703, Pyrococcus = 11/1305, human-mouse-rat= 16/2112).