Words similar to htnf-α
Example sentences for: htnf-α
How can you use “htnf-α” in a sentence? Here are some example sentences to help you improve your vocabulary:
The murine anti-TNF-α mAb used in this study binds with high affinity to hTNF-α and prevents binding to the TNF receptor [ 10 ] . Anti-TNF-α mAb was administered by intraperitoneal injection at 10 mg/kg weekly and the animals in the control group received weekly injections of saline.
Progression of established polyarthritis in the Tg197 hTNF-α transgenic mouse can be reversed by treatment with anti-TNF-α mAb, as shown by significant improvement in clinical and histological scores.
Interestingly, local expression of murine TNF-α mRNA was not affected by treatment with anti-TNF-α antibodies, suggesting that hTNF-α plays a crucial role in the pathogenesis of arthritis in this model.
Heterozygous Tg197 transgenic mice, obtained from Dr George Kollias (Hellenic Pasteur Institute, Athens, Greece) [ 7 ] , were identified by PCR analysis using primers to the 3'-modified hTNF-α gene.
First, circulating hTNF-α levels as detected by ELISA were more than halved as early as 3 weeks and the reduction was sustained for 16 weeks after treatment with anti-TNF-α mAb in comparison with saline-treated animals (Fig.