Example sentences for: hot-spot

How can you use “hot-spot” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Sequence analysis of the TK coding region from all five plaque isolates identified a G nucleotide insertion in the homopolymeric hot-spot G7 tract at nucleotide 435, a common mutation present in other ACV rHSV isolates [ 18 19 ] . This base insertion produced a frame shift in the coding sequence, resulting in a loss of the ATP / nucleoside-binding site and the creation of a premature stop codon at amino acid 228 to encode a truncated 28 kD TK polypeptide.


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