Example sentences for: hormone-dependent

How can you use “hormone-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The hormone-dependent component of the ERβ /N-CoR interaction maps to the extreme C-terminus of N-CoR, which has not been previously implicated in NR interactions, and requires a sequence that resembles an ERβ-specific NR box (PLTIRMLS, β-box).

  • In order to investigate further whether reduction of BRCA1 protein had an effect on hormone-dependent cell growth, BG-1 antisense and control cells were grown in estrogen-deprived conditions for an extended period of time.

  • The finding that estrogens suppress N-CoR binding to ERα [ 39 ] , but promote N-CoR binding to ERβ represents the first demonstration of a corepressor that shows completely distinct modes of hormone-dependent interaction with the ER isoforms.

  • In addition, it has been demonstrated [ 20] that hormone-dependent tumors such as breast and ovarian cancers have a decreased ability to undergo apoptosis.

  • NRs consist of three domains, the N-terminal domain (which contains a context-specific activation function AF-1), the central DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD), which contains a hormone-dependent activation function, AF-2.


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