Words similar to homoplasmic

Example sentences for: homoplasmic

How can you use “homoplasmic” in a sentence? Here are some example sentences to help you improve your vocabulary:

A homoplasmic T3197C nucleotide substitution was detected in this patient's blood and muscle and it was also detected on the proband's mother and on two half siblings.
Both mother and child were found to have two common polymorphisms in homoplasmic state, G185A and A73G.
An obvious difference was found in the D-loop region where A189G was present in the proband in a near homoplasmic state and homoplasmic wild type A189 was present in the proband's mother.
Further investigations are necessary to define the clinical significance of the homoplasmic mtDNA alterations found in the proband and to know whether they may act as secondary mutations, synergistically with a primary defect (either nuclear or mitochondrial) that could affect the mitochondrial function and result in this clinical condition.
At the present time, the T3197C nucleotide substitution is considered a polymorphism and it is not thought to have pathogenic significance by itself [ 31 ] . Although most pathogenic mutations are heteroplasmic, many homoplasmic mutations have been reported to have synergistic effects in the presence of other primary mutations [ 32 33 ] . The only difference in mtDNA between the affected child and the asymptomatic mother is the A189G mutation in the hypervariable D-loop region.