Words similar to histocompatibility
Example sentences for: histocompatibility
How can you use “histocompatibility” in a sentence? Here are some example sentences to help you improve your vocabulary:
The role of genetics in modulating the immune response to infectious diseases is a topic of longstanding interest among epidemiologists, clinicians, population geneticists, and immunologists [ 1 2 ] . Zinkernagel and Doherty's Nobel Prize-winning discovery that cellular immunity to viral infections was "restricted" by the highly variable proteins of the Major Histocompatibility Complex (MHC) brought the field of immunogenetics into sharper focus [ 3 ] . Their demonstration that T lymphocytes recognize virus antigens displayed on a host cell "in the context of" MHC proteins immediately suggested the idea that genetic differences at the loci encoding the MHC might modulate the intensity and effectiveness of host response to infection.
TCR, T cell receptor; MHC, major histocompatibility complex; H-2, murine MHC locus; Tag, SV40 T antigen; RIP, rat insulin promoter; RAG, recombinase activating gene.
CTLs specifically recognize and lyse targets through the interaction of T cell receptors (TCRs) on the surface of the T lymphocyte with protein fragments (peptides) presented on the surface of target cells, in association with major histocompatibility complex (MHC) class I molecules.
For example, 80% of the over 900 olfactory genes are found in clusters of 6-138 genes [ 22 ] . The 3.6 Mbp human major histocompatibility complex (MHC) on chromosome 6p21.
For instance, HIV-1 infection is able to down-regulate major histocompatibility complex type I (MHC-I) by various different viral proteins, including Tat which represses the transcription of MHC-I, Vpu which retains nascent MHC-I chains in the endoplasmic reticulum, and Nef which can mediate selective internalization of MHC-I molecules from the plasma membrane.
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