Words similar to high-affinity
Example sentences for: high-affinity
How can you use “high-affinity” in a sentence? Here are some example sentences to help you improve your vocabulary:
In designing an NFATp-responsive DNA template, we positioned three high-affinity NFAT-binding sites upstream of the adenovirus E1b TATA box and the CAT gene.
This pattern of mutations has been described for cold agglutinins [ 32], as well as for rheumatic factors, as a mechanism of selection against amino acid replacement to prevent the generation of high-affinity autoantibodies [ 33].
These studies revealed that the suppression of PP5 expression had no apparent effect on dexamethasone binding, suggesting that PP5 does not affect the formation of the high-affinity ligand binding complex or hormone binding to the GR [ 25].
BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
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