Words similar to high-affinity
Example sentences for: high-affinity
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This interaction unclasps the complex between the cytoplasmic tails, which then allows a conformational shift in the extracellular domain from a bent to a more extended form for high-affinity ligand binding (Figure 1) (Takagi et al.
These studies revealed that the suppression of PP5 expression had no apparent effect on dexamethasone binding, suggesting that PP5 does not affect the formation of the high-affinity ligand binding complex or hormone binding to the GR [ 25].
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The high-affinity IL-2 receptor is comprised of three subunits, α, β and γ [ 46 47 ] . The α chain is specific to IL-2, while the γ chain is shared among IL-4, IL-7, IL-9, IL-15 and IL-21 [ 48 ] . The β chain of the IL-2R is also a component of the IL-15 receptor, in conjunction with a specific IL-15R α chain [ 49 ] . The sharing of these receptors by multiple cytokines raises the question of how the ligands can trigger specific responses in the target cells.
The use of clinical-grade high-affinity antibodies in this format would presumably allow a corresponding increase in sensitivity.
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