Words similar to heterooligomeric

Example sentences for: heterooligomeric

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Similarly, β-TRCP1 and 2, which target IκBα for degradation as homooligomers, form heterooligomers that each bind SCF core subunits, although no biochemical activity for this heterooligomeric complex was demonstrated [ 29 ] . Finally, Pop1p and Pop2p homooligomerize, at least when overexpressed [ 18 ] , indicating that both F-box proteins may also be present as homooligomers in individual SCF Pop1pand SCF Pop2p, respectively.
In addition, based on overexpression, distinct SCF Pop1pand SCF Pop2pcomplexes were proposed to target unknown substrates, but no biochemical evidence of their activity was provided [ 18 ] . To address these questions, we cloned two additional subunits of SCF Popand performed a detailed characterization of its activity in vitro and in vivo . Our results indicate that heterooligomeric SCF Pop1p-Pop2pmediates Rum1p ubiquitylation whereas distinct SCF Pop1pand SCF Pop2pcomplexes target unknown nuclear and cytoplasmic substrates, thereby generating combinatorial diversity of SCF function in fission yeast.
Whether this unusual heterooligomeric SCF Pop1p-Pop2pcomplex exists in vivo and whether it mediates Rum1p ubiquitylation, remained unproven, as not all fission yeast SCF core subunits were identified.
A heterooligomeric SCF Pop1p-Pop2pcomplex mediates polyubiquitylation of phosphorylated Rum1p.