Example sentences for: heterooligomeric

How can you use “heterooligomeric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Whether this unusual heterooligomeric SCF Pop1p-Pop2pcomplex exists in vivo and whether it mediates Rum1p ubiquitylation, remained unproven, as not all fission yeast SCF core subunits were identified.

  • Similarly, β-TRCP1 and 2, which target IκBα for degradation as homooligomers, form heterooligomers that each bind SCF core subunits, although no biochemical activity for this heterooligomeric complex was demonstrated [ 29 ] . Finally, Pop1p and Pop2p homooligomerize, at least when overexpressed [ 18 ] , indicating that both F-box proteins may also be present as homooligomers in individual SCF Pop1pand SCF Pop2p, respectively.

  • In addition, based on overexpression, distinct SCF Pop1pand SCF Pop2pcomplexes were proposed to target unknown substrates, but no biochemical evidence of their activity was provided [ 18 ] . To address these questions, we cloned two additional subunits of SCF Popand performed a detailed characterization of its activity in vitro and in vivo . Our results indicate that heterooligomeric SCF Pop1p-Pop2pmediates Rum1p ubiquitylation whereas distinct SCF Pop1pand SCF Pop2pcomplexes target unknown nuclear and cytoplasmic substrates, thereby generating combinatorial diversity of SCF function in fission yeast.

  • A heterooligomeric SCF Pop1p-Pop2pcomplex mediates polyubiquitylation of phosphorylated Rum1p.


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