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Example sentences for: henikoff

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In the report by Chasman and Adams, evolutionary information was predicted to be a useful component in determining whether a mutation is deleterious [ 13 14 ] . Disease causing mutations are also likely structurally perturbing at the protein level [ 15 ] . Ng and Henikoff have introduced SIFT, a method for predicting functional SNPs from a database of unannotated polymorphisms [ 16 17 ] .
This was done by the method of Henikoff & Henikoff [ 19 ] , as previously described [ 20 ] . In summary, the first step was to weight each sequence in a multiple sequence alignment block according to its degree of similarity to the other sequences, which has the effect of minimizing the influence of highly redundant sequences in the final profile.
These weights were calculated according to the method of Henikoff & Henikoff [ 21 ] , which is based on the residue diversity at each position of the alignment.