Words similar to helix
Example sentences for: helix
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Repetitive proline sequences tend to adopt a polyproline II (PPII) helix, consisting of an extended structure with three residues per turn.
For example, the junction between the aptamer and the Group I ribozyme in the aptazyme Th2P6 resembled the deletion variant td ΔP6-6; the aptazyme was activated by theophylline, while the splicing defect of the deletion variant at 3 mM magnesium was suppressed by 8 mM magnesium or by stabilization of a tetraloop sequence that capped the P6 helix [ 15 ] . Defects that poise a ribozyme between active and inactive conformers have previously been used to engineer effector-dependence [ 20 ] .
The crystal structure of the PP5 TPR domain revealed three TPRs followed by an extended α helix [ 24 ] , however Ppt1p was originally proposed to contain one additional TPR [ 2 ] . The pattern of proteolysis and sites of cleavage for Ppt1p are very similar to those seen with PP5 under these same conditions [ 19 ] . This indicates that Ppt1p also contains an accessible region linking the TPR and catalytic domains and is most consistent with the presence of three TPRs in Ppt1p.
The residues K10, the backbone of S11, V12, V12, S14, V17, G40, E55, K63 and 64V, from the kinked carboxy-terminal helix, a beta-turn, and parts of the beta-sheet, define a putative binding epitope (Figure 2b).
Although the α5 helix (Figure 1) does not directly contact the bound guanine-nucleotide [ 19 20 21 ] , it is clearly important for Gα structure and to maintain the proper orientation of the β6-α5 loop.
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