Example sentences for: helicase

How can you use “helicase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The highly acidic carboxy-terminal (BRCT) region of BRCA1 has been suggested to play a role in transactivation [ 11 ] . BRCT interacts with BRCA2, Rad51, other tumor suppressing elements, as well as numerous transcription factors, such as RNA helicase A and STAT1 [ 15 16 ] . Recently, it has been discovered that truncation of this region resulted in suppression of apoptosis following pro-apoptotic stimuli [ 17 ] . Further, these studies also suggested that the BRCT region facilitates apoptotic functions within the caspase pathway.

  • The helicase and C-terminal mutations of BLM have very different effects compared to the N-terminal mutations

  • BLM, the gene mutated in BS, encodes a DNA helicase (BLM) of the RecQ family [ 3].

  • The BLM DNA helicase is found in two distinct nuclear structures in normal human cells, ND10 or PML nuclear bodies (NBs) and the nucleolus [ 20].

  • They have long GC-rich 5'-UTRs that can form extensive secondary structure and have been classified as "weak" mRNAs because they are translated inefficiently when eIF4E levels are limiting (reviewed in [ 15 ] ). It has been proposed that when eIF4E levels are elevated these mRNAs can more effectively recruit eIF4E and its associated factors including eIF4G, a scaffold protein essential in recruiting the small ribosomal subunit, and eIF4A, a helicase essential for scanning through secondary structures in the 5'-UTR [ 15 27 ] .


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