Words similar to hedgehog
Example sentences for: hedgehog
How can you use “hedgehog” in a sentence? Here are some example sentences to help you improve your vocabulary:
Across on Hess András tér, the bas-relief of a red hedgehog at number 3 recalls the 18th century, when the building was an inn of that name.
To examine the effect of Sonic hedgehog (Shh) (R&D Systems), we added 300 nM mouse Shh in PBS every other day during stage 4. To quantify neurite outgrowths per cluster, 20 Shh-treated or control stage 4 IPC clusters were photographed under light microscopy, and digitized images were used to score neurites.
We detected expression of the Hedgehog receptors Patched (Ptc) and Smoothened (Smo) at all stages (Figure 3B), consistent with the possibility that NS-derived cells are competent for Hh signaling.
The hedgehog ( hh ) gene was identified two decades ago in Drosophila as a critical regulator of cell-fate determination during embryogenesis [ 1 ] . Subsequent work in several model systems has defined and characterized the Hh gene family that encodes highly conserved secreted signaling proteins (for review see [ 2 ] ). Hedgehog (Hh) proteins are synthesized as approximately 45 kDa precursors that autoprocess in an unprecedented fashion, resulting in the covalent attachment of a cholesterol moiety to the amino-terminal half of the precursor [ 2 ] . This processed amino-terminal domain, Hh-Np, is responsible for the activation of a unique and complex signaling cascade that is essential for controlling cell fate throughout development and into adulthood [ 2 ] . In mammals there are three Hh-family proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh).
Gorlin's syndrome results from inherited mutations in the Hedgehog receptor PTCH that constitutively activate the pathway.
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