Example sentences for: h-r
How can you use “h-r” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of these is typified by the candidate tumor suppressor protein, H-rev107, which inhibits growth of tumors induced by the oncoprotein H-Ras [ 58].
Rab24 contains a unique arginine-rich insert, 126EEDRRRRR 133 [ 25 ] in the domain cognate to loop-8 in H-Ras [ 34 ] . The latter sequence is reminiscent of unusual arginine-rich nuclear localization signals that allow proteins like HIV tet and rev to undergo nuclear translocation by association with importin-β, in the absence of importin-α [ 45 46 ] . Since the loop-8 insert in Rab24 lies adjacent to the conserved N(T)KxD nucleotide binding cassette, we hypothesized that conformational changes caused by the D123I substitution might render the Rab24 mutant capable of disrupting the nuclear import machinery [ 47 ] . To test this possibility, we co-expressed mycRab24wt or mycRab24(D123I) with GR-GFP, a fusion between the glucocorticoid receptor and green fluorescent protein.
We have described several unusual features of Rab24 that distinguish it from all other members of the Rab family studied to date [ 25 ] . Rab24 has a markedly reduced GTPase activity, due primarily to the presence of a serine residue instead of the usual glutamine at the position equivalent to Q61 in H-Ras.
In all of the known Ras-related GTPases the guanine nucleotide binding site is surrounded by a set of highly conserved sequence elements [ 33 34 ] . One of these elements, termed the G2 motif, consists of NKxD (with the asparagine located at position 116 in H-Ras).
Amino acid substitutions at the position cognate to N116 in H-Ras typically yield soluble Rab proteins that have a reduced affinity for guanine nucleotides.
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