Words similar to gα
Example sentences for: gα
How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:
The family of RGS proteins are established to interact with various Gα-protein subunits, thereby antagonizing their activities [ 13 14 15 16 17 18 24 ] . Indeed, we previously reported that RGS3 bound Gqα [ 9 ] , the G protein subunit that mediates GnRH receptor signaling [ 38 ] . Here, we have extended those binding studies to include other Gα proteins (Fig.
Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the Gα protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.
A number of reports have demonstrated that disruptions in the C-termini of Gα cause reduced affinity for guanine-nucleotides and protein instability.
These results suggest that both sα i2 and α i2 A327S may prove valuable in future studies of mechanisms of degradation of Gα.
The A326S mutation of α i1 and A366S mutation of α s (cognate to the α i2 A327S used in this study) were shown to cause greatly decreased affinity for GDP [ 9 10 ] . Defective binding of GDP leads to more Gα in the empty state (no bound guanine-nucleotide), and this form of Gα is rapidly denatured in vitro , as shown for α s A366S and α i1 A326S [ 9 10 ] . Moreover, α s A366S was demonstrated to undergo rapid degradation (t 1/2 < 1 h) in stably transfected cells [ 9 ] . The same mutation in α t has also been shown to greatly decrease guanine-nucleotide binding [ 5 22 ] . Additional amino acids in the critical β6-α5 loop are important for maintaining Gα integrity [ 7 ] .
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