Words similar to gα
Example sentences for: gα
How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Unique subcellular localization has been observed for a novel alternative spliced form of the G protein α subunit (Gα), α i2 [ 3 ] . This α i2 splice variant, termed sα i2 , contains a novel 35 amino acid sequence that replaces the C-terminal 24 amino acids of α i2 [ 3 ] . sα i2 has been observed to localize to Golgi membranes and other intracellular membranes [ 3 4 ] ; in contrast, wild type α i2 is typically found at PM.
Earlier, we presented evidence that a regulator of G protein signaling, RGS3, might participate in the regulation of GnRH receptor signaling [ 9 ] . The mechanism of RGS action is antagonism of the Gα protein either by accelerating its hydrolysis of GTP, thereby prematurely terminating signaling due to reassociation of the Gα and Gβγ complexes [ 10 ] , or by antagonizing interaction of the Gα protein with its effector such as phospholipase Cβ [ 11 12 ] . A large number of RGS genes have been identified in mammals based on the presence of a 120 amino acid core domain [ 13 14 15 16 ] . RGS proteins have been described that interact with the G i α and G qα members of the G protein family [ 17 18 19 20 21 ] .
The observed intracellular membrane (ER) localization and proteasome inhibitor-induced juxtanuclear aggregate accumulation (aggresome) is consistent with that reported for other proteins being degraded by such a pathway [ 18 24 ] . When treated with proteasome inhibitors, overexpressed wild type α i2 also accumulates in aggresome-like structures (Figure 7), suggesting that Gα may normally be degraded by a proteasome-dependent pathway.
GPCRs stimulate heterotrimeric G proteins which release activated Gα and Gβγ subunits to interact with a variety of effectors.
Several studies have shown that deletions or amino acid substitutions in the extreme C-terminal region of Gα creates a protein defective in guanine-nucleotide binding [ 5 6 7 8 9 10 ] . Rapid release of guanine-nucleotides can result in an unstable Gα [ 9 10 ] . This leads to the prediction that sα i2 is also unstable due to a disruption in the structure of its C-terminus caused by the novel splice sequence.
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