Words similar to gα
Example sentences for: gα
How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:
These results suggest that both sα i2 and α i2 A327S may prove valuable in future studies of mechanisms of degradation of Gα.
The C-terminal 30 amino acids of Gα consist of the β6-α5 loop, followed by the α5 helix and finally several amino acids of flexible structure (Figure 1) [ 19 20 21 ] . The β6-α5 loop stabilizes the guanine ring of bound GDP or GTP, and mutations in this region affect guanine-nucleotide binding.
Although the α5 helix (Figure 1) does not directly contact the bound guanine-nucleotide [ 19 20 21 ] , it is clearly important for Gα structure and to maintain the proper orientation of the β6-α5 loop.
Second, the extreme C-termini of Gα are critical sites for interaction with GPCRs [ 32 ] , and the novel C-terminal sequence found in sα i2 would be predicted to disrupt productive interactions with GPCRs.
Earlier, we presented evidence that a regulator of G protein signaling, RGS3, might participate in the regulation of GnRH receptor signaling [ 9 ] . The mechanism of RGS action is antagonism of the Gα protein either by accelerating its hydrolysis of GTP, thereby prematurely terminating signaling due to reassociation of the Gα and Gβγ complexes [ 10 ] , or by antagonizing interaction of the Gα protein with its effector such as phospholipase Cβ [ 11 12 ] . A large number of RGS genes have been identified in mammals based on the presence of a 120 amino acid core domain [ 13 14 15 16 ] . RGS proteins have been described that interact with the G i α and G qα members of the G protein family [ 17 18 19 20 21 ] .
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