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How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Such instability is consistent with known structure-function data regarding the importance of the C-terminus of subunits.

  • A number of reports have demonstrated that disruptions in the C-termini of cause reduced affinity for guanine-nucleotides and protein instability.

  • The observed intracellular membrane (ER) localization and proteasome inhibitor-induced juxtanuclear aggregate accumulation (aggresome) is consistent with that reported for other proteins being degraded by such a pathway [ 18 24 ] . When treated with proteasome inhibitors, overexpressed wild type α i2 also accumulates in aggresome-like structures (Figure 7), suggesting that may normally be degraded by a proteasome-dependent pathway.

  • Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.

  • Based on this unique localization of sα i2 , a prominent role in membrane trafficking has been proposed for this subunit [ 3 ] . However, no report to date has supported a functional role for sα i2 in vesicular transport, although a variety of functional assays have implicated other , including α s and α i3 , in vesicle trafficking pathways [ 1 2 ] .


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