Words similar to gα
Example sentences for: gα
How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:
These results suggest that both sα i2 and α i2 A327S may prove valuable in future studies of mechanisms of degradation of Gα.
A specific combination of β and γ subtypes may play such a role; however, one thorough study showed a lack of βγ on Golgi membranes of exocrine pancreatic cells even though a variety of Gα were readily detected in the Golgi [ 33 ] . Other proteins that may specifically promote the intracellular targeting of Gα have not been identified.
Taken together, results with βγ co-expression are consistent with the ability of βγ to promote PM targeting of Gα, and further suggest that sα i2 is less effectively stabilized than α
These results are also consistent with the possibility that the primary defect in sα i2 is a reduced ability to interact with βγ; Gα containing mutations in known sites of contact with βγ fail to localize to PM, but over-expression of βγ can rescue their PM localization [ 28 29 ] . However, the crystal structures [ 30 31 ] show that the C-terminal β6-α5 loop/α5 helix region does not directly contact βγ.
The A326S mutation of α i1 and A366S mutation of α s (cognate to the α i2 A327S used in this study) were shown to cause greatly decreased affinity for GDP [ 9 10 ] . Defective binding of GDP leads to more Gα in the empty state (no bound guanine-nucleotide), and this form of Gα is rapidly denatured in vitro , as shown for α s A366S and α i1 A326S [ 9 10 ] . Moreover, α s A366S was demonstrated to undergo rapid degradation (t 1/2 < 1 h) in stably transfected cells [ 9 ] . The same mutation in α t has also been shown to greatly decrease guanine-nucleotide binding [ 5 22 ] . Additional amino acids in the critical β6-α5 loop are important for maintaining Gα integrity [ 7 ] .
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