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How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Such instability is consistent with known structure-function data regarding the importance of the C-terminus of subunits.

  • The C-terminal 30 amino acids of consist of the β6-α5 loop, followed by the α5 helix and finally several amino acids of flexible structure (Figure 1) [ 19 20 21 ] . The β6-α5 loop stabilizes the guanine ring of bound GDP or GTP, and mutations in this region affect guanine-nucleotide binding.

  • A specific combination of β and γ subtypes may play such a role; however, one thorough study showed a lack of βγ on Golgi membranes of exocrine pancreatic cells even though a variety of were readily detected in the Golgi [ 33 ] . Other proteins that may specifically promote the intracellular targeting of have not been identified.

  • Unique subcellular localization has been observed for a novel alternative spliced form of the G protein α subunit (), α i2 [ 3 ] . This α i2 splice variant, termed sα i2 , contains a novel 35 amino acid sequence that replaces the C-terminal 24 amino acids of α i2 [ 3 ] . sα i2 has been observed to localize to Golgi membranes and other intracellular membranes [ 3 4 ] ; in contrast, wild type α i2 is typically found at PM.

  • In spite of its unknown functional significance, sα i2 provides a potential model for studying mechanisms of subcellular localization of .


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