Words similar to gα
Example sentences for: gα
How can you use “gα” in a sentence? Here are some example sentences to help you improve your vocabulary:
In spite of its unknown functional significance, sα i2 provides a potential model for studying mechanisms of subcellular localization of Gα.
Taking the G protein-coupled receptors (GPCRs) as an example, after agonist action, GPCRs activate G proteins and become phosphorylated by G protein-coupled receptor kinases [ 23 ] . This event promotes activation of effector enzymes and ion channels by the activated Gα GTP.
Although the α5 helix (Figure 1) does not directly contact the bound guanine-nucleotide [ 19 20 21 ] , it is clearly important for Gα structure and to maintain the proper orientation of the β6-α5 loop.
Taken together, results with βγ co-expression are consistent with the ability of βγ to promote PM targeting of Gα, and further suggest that sα i2 is less effectively stabilized than α
These results are also consistent with the possibility that the primary defect in sα i2 is a reduced ability to interact with βγ; Gα containing mutations in known sites of contact with βγ fail to localize to PM, but over-expression of βγ can rescue their PM localization [ 28 29 ] . However, the crystal structures [ 30 31 ] show that the C-terminal β6-α5 loop/α5 helix region does not directly contact βγ.
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