Words similar to gyrase
Example sentences for: gyrase
How can you use “gyrase” in a sentence? Here are some example sentences to help you improve your vocabulary:
The sequence immediately flanking the dnaA gene is considered the origin of chromosomal replication, or oriC region [ 9 10 ] . This region contains several genes that encode proteins required for basic cellular functions, including the protein subunit of RNase P (RnpA), ribosomal protein L34 (RpmH), the replication initiator protein (DnaA), the beta subunit of DNA polymerase III (DnaN), the recombination repair protein RecF, and the DNA gyrase proteins GyrA and GyrB.
The B-subunit of DNA polymerase is encoded by dnaN . The recF gene product is involved in recombination, DNA repair, and induction of the SOS response, and may also have a role in replication [ 17 ] . Bacterial DNA gyrase, a tetramer consisting of A and B subunits, catalyzes the ATP-dependent unwinding of covalently closed circular DNA [ 18 ] . The remaining predicted ORFs in this region have high similarity to hypothetical proteins from M. tuberculosis (Table 1).
While novobiocin acts primarily as a DNA gyrase inhibitor, resistance is mediated by the concentration of phospholipids in the outer membrane, for which the cls gene (encoding cardiolipin synthase) is partly responsible [ 33 ] . Again, if selection had increased membrane permeability, sensitivity to novobiocin might have increased relative to the partially resistant ancestor.
These newly detected domains included the SUI1 domain, that is found in eIF1 and related proteins [ 78 ] , the third globular domain of DNA gyrase/Topoisomerase II and, most interestingly, a distinct globular domain in the yeast DDRP β' subunit (PDB: 1k83; region 1143-1271).
Escherichia coli DNA topoisomerase I is a representative example of type IA DNA topoisomerase (for reviews, see refs [ 1 2 ] ). Its major biological role in the bacterial cell is the removal of excessive negative supercoils from DNA to maintain the DNA at optimal superhelical density along with DNA gyrase [ 3 ] . The enzyme has a molecular weight of 97 kDa and the active site tyrosine responsible for DNA cleavage is found in the 67 kDa N-terminal transesterification domain.
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