Example sentences for: groove

How can you use “groove” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The efficient prediction of peptide side-chain conformations in the groove has been shown mainly due to van der Waals contribution.

  • And groove could simply mean a "style," a sense associated with the parallel between being in a groove and being in a rut . (In the 19 th century, groovy actually meant "to be in a rut" or to be "of settled habits" or "conventional"; the first Oxford English Dictionary citation for this kind of grooviness is dated 1867.)

  • CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .

  • Hence, SS interactions are crucial for proper anchoring of short peptides within the groove.

  • Let us modify the device such that the cannonball, after hitting the paddle wheel and setting it spinning, is deflected downward onto the ground and digs a long shallow groove in the dirt, with high sides due to the displaced dirt.


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