Words similar to grk

Example sentences for: grk

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The opossum alpha-2C adrenergic receptor has a EESSTSE acidic serine/threonine motif in the third intracellular loop (Figures 1and 2), which could be a substrate for GRK based on the EESSSSD motif of the alpha-2A subtype.
Initial uncoupling of the beta-2 receptor from the G protein after agonist binding is mediated by phosphorylation by G protein-coupled receptor kinase (GRK) of specific residues in the carboxyl tail of the receptor.
Site-directed mutagenesis studies indicate that all four of these serines are phosphorylated by GRK, and all four are needed for desensitization [ 12 ] . The influence of this motif on down-regulation was not investigated, however.
One of these is Grk2 , a member of the family of ionotropic glutamate receptor genes that is thought to play a role in modulating Huntington disease [ 44].
The expressed 5-HT 2C receptor exhibits homologous and heterologous desensitization in oocytes [ 32 ] mediated by protein kinase C [ 33 34 35 ] . A calmodulin-dependent kinase may also be involved in homologous desensitization [ 36 ] . In contrast, a recent study indicates that neither PKC nor calmodulin-dependent protein kinase II are involved, instead desensitization of the 5-HT 2C receptor is dependent on GRK activity [ 37 ] . Interestingly, tyrosine kinase involvement in the agonist-mediated phosphorylation of the rat 5-HT 2C receptor has also been reported [ 38 ] , although as yet no report has shown that the 5-HT 2C receptor directly activates tyrosine kinases.